Miniaturization of an Epigenetic HTRF® Assay with the Labcyte® Echo® Liquid Handler
12 Mar 2015Epigenetics is emerging as an important target class for drug discovery and cancer research. As programs scale to evaluate new targets related to epigenetic expression, new tools are required to enable efficient high-throughput epigenetic screening. This poster shows the development of a methyltransferase assay in a 5 μL final volume with excellent results. It also demonstrates further miniaturization opportunities for screening and inhibitor characterization.
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Echo® 500 Series Liquid Handlers
The Echo® liquid handler revolutionizes liquid handling with acoustic energy. Sound waves eject precisely sized droplets from a source onto a microplate, slide or other surface suspended above the source. This product does not use tips, pin tools or nozzles—completely eliminating contact between the instrument and the liquid. The Echo liquid handler provides powerful benefits: Tipless transfer, resulting in dramatic cost savings Improved information about sample integrity and improved transfer quality through measurement of DMSO hydration level Elimination of the need for calibration through Dynamic Fluid Analysis™ technology, a patented Labcyte process Elimination of cross-contamination, carryover or leachates through non-contact transfer Accurate, precise movement of nanoliter-scale quantities, enabling assay miniaturization and further reducing costs Better results through direct dilution of compounds, an improvement over serial dilution methods Greatly simplified assay development and dilution processes through the flexibility to transfer any volume of liquid from any well to any other well