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Microanalysis in Pharmaceutical Product Development and Trouble-Shooting

Bruker Optics
21 Nov 2018

The demand on the quality of pharmaceutical products is very high. Raw and packaging materials as well as intermediate and final products must contain the correct components and need to be free from contaminations. In quality control analytical methods like Mid- and Near-IR spectroscopy and others allow to verify an overall correct identity and composition of the sample. However, contaminants like particles in liquid formulations or inclusions in tablets are often extremely small and cannot be detected selectively by such macroscopic methods. Therefore further analytical methods are needed to determine the accurate chemical nature of the particle or inclusion – valuable information that allows to find the source of contamination.

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LUMOS II FTIR Imaging Microscope

Bruker Optics

The LUMOS II offers outstanding visual and spectral data quality with full automation of all measurement modes: transmission, reflection and ATR. For FTIR beginners and experts alike, the LUMOS II is the best solution for infrared microscopy. Bruker's exclusive Focal Plane Array (FPA) detector technology allows you to experience detailed imaging at the maximum speed. This allows you to take full advantage of the vast possibilities offered by FTIR microscopy. The OPUS IR software provides you with assistance whenever you need it and allows you to glide effortlessly through measurement, evaluation and reporting. Your advantages: Extremely fast FTIR imaging (FPA) High spectral quality and resolution Brilliant visual images and huge field of view Fully automated FTIR microscope Integrated, piezo-controlled ATR crystal Software supported measurement and evaluation Automatic measurement in transmission, reflection and ATR Plenty of space between sample stage and lens Analyze samples up to 40 mm in height

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Infrared / IR SpectroscopyInfrared (IR) spectroscopy measures the interaction of infrared light with a sample, including transmission, reflectance & absorbance, facilitating the identification of analytes. Equipment used for quantitative analysis includes Fourier-transform infrared (FTIR) spectrometers, infrared cameras, FTIR gas analyzers, as well as attenuated total reflectance (ATR) accessories and pellet or film presses. Find the best IR spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.UV-Visible-NIRUV-Visible-NIR spectroscopy is used to analyze a wide range of samples based on their absorption of ultraviolet, visible, and near-infrared light. It is commonly applied in chemical analysis, material science, and quality control. Browse our peer-reviewed product directory to find the best UV-Visible-NIR spectroscopy systems, compare products, check reviews, and get pricing directly from manufacturers.SpectroscopySpectroscopy is a technique that analyzes the interaction of light with matter to study molecular properties, concentrations, and structural information. Widely used in chemical, pharmaceutical, and environmental analysis, spectroscopy offers insights into molecular composition and helps identify unknown compounds. It plays a key role in quality control, research, and diagnostics. Browse our peer-reviewed product directory to compare spectroscopy tools, read reviews, and get prices directly from manufacturers.PharmaceuticalsPharmaceuticals are medicinal drugs used in healthcare to diagnose, prevent, cure and treat illnesses. Pharmaceuticals that are excreted after use appear in wastewater and can have detrimental effects on the environment.InfraredDrug DevelopmentDrug development refers to the process of bringing a new drug to market.

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Microanalysis in Pharmaceutical Product Development and Trouble-Shooting