ResourceLife Sciences
Label-Free SPR Binding Assays in Lead Finding for an Orphan Nuclear Receptor
17 Oct 2010Orphan receptors provide opportunities to characterize novel signal transduction pathways and new potential drug targets This application poster applies Surface plasmon resonance (SPR), thermal stability and mass spectrometry (MS) to an NR target. Through this target approach an X-Ray structure of this orphan NR could be obtained with one of the compound discovered in this process.
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ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.