Label-Free CAR-T Cell Assays with the Corning® Epic® BT: A High Throughput Kinetic System
15 May 2017Chimeric antigen receptor (CAR)-T cells, which contain a single chain variable fragment to recognize tumor cell surface antigens, have shown promise as a new tool in immunotherapy, with best case clinical results of total cancer remission in patients with B-cell lymphoma. This study demonstrates that the Corning Epic BT system is capable of performing label-free kinetic CAR-T assays at physiologically relevant temperatures.
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Corning® 384-well Black/Clear Round Bottom Ultra-Low Attachment Spheroid Microplate, Bulk Packed 10 per Bag, with Lid, Sterile
Corning Life SciencesUltra-Low Attachment microplates feature a covalently bound hydrogel layer that effectively inhibits cellular attachment Surface minimizes protein absorption, enzyme activation and cellular activation Surface is noncytotoxic, biologically inert and nondegradable Sterilized by gamma irradiation Black wall microplates have low background fluorescence, minimal light scatter and reduced crosstalk Opaque walls to prevent well-to-well crosstalk Can be used for both top and bottom reading instruments Bulk packed 10 per bag Novel well geometry aids formation of spheroids in center of well Optically clear round bottom with black opaque microplate body