Impact of the Claristep Filtration System on Recovery and Adsorption of Various Therapeutic Proteins at Low Sample Volumes

Biopharmaceutical samples often contain insoluble particles like cell debris or protein aggregates from their biotechnological production processes. These particles can damage analytical instruments, e.g. by blocking capillaries of auto-samplers of analytical devices or chromatography columns, and are typically removed by centrifugation or filtration. Whereas centrifugation can only separate based on differences in density, the latter method is often preferable because an absolute particle removal can be achieved.