HPLC method to differentiate four THC stereoisomers formed from Δ9-THC degradation

29 Jul 2021

Degradation of Δ9-THC to Δ10-THC and Δ6a,10a-THC isomers, provides a challenging separation in cannabis-derived products. In this application note, learn how the use of an immobilized cellulose chiral column under normal-phase liquid chromatography conditions provides an analytical method to fully separate these four THC isomers for identification and accurate determination of potency.

Phytocannabinoid Mixture 11 (CRM) (1 ml, 250 µg/ml)

Cayman Chemical Co.

Phytocannabinoid Mixture 11 (CRM) (1 ml,  250 µg/ml) (Item No. 21306) is a certified reference material mixture provided as a DEA exempt preparation. Included are Δ9-THC, Δ8-THC, tetrahydrocannabinolic acid A, cannabinol, cannabidiol, cannabidiolic acid, (±)-cannabichromene, cannabigerol, cannabigerolic acid, cannabidivarin, and tetrahydrocannabivarin. It is supplied in an amber ampule in which the headspace has been purged with argon.

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HPLC method to differentiate four THC stereoisomers formed from Δ9-THC degradation