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GC-TOFMS Study on Common Drugs of Abuse: Diphenylhydramine, Orphenadrine, Propoxyphene, Amitryptyline and Dothiepin

21 May 2012

This note describes the analysis of some common drugs of abuse by Gas Chromatography—Time-of-Flight Mass Spectrometry (GC-TOFMS). In addition to using standards, two real-life samples of blood and urine extracts were analyzed to demonstrate the power of the technique in handling samples containing small amounts of drugs in demanding matrices.

Pegasus® GC-HRT

LECO Corp.

While some systems on the market offer users a choice between acquisition speed or resolution, the Pegasus GC-HRT provides scientists with an unprecedented combination of speed, resolution, mass accuracy, isotopic abundance, and dynamic range. This instrumentation utilizes LECO's own Folded Flight Path™ (FFP™) technology to allow users to achieve resolutions of up to 50,000. LECO's exclusive ChromaTOF-HRT™ software with Automated Peak Find and True Signal Deconvolution® provides seamless data handling and compatibility with the NIST Library.

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