From sample to species: Automated MALDI-TOF MS workflows for streamlined bacterial identification

26 Feb 2026

Identifying bacteria accurately and efficiently is essential in numerous fields, from ensuring food safety to monitoring environmental health and diagnosing infections. Traditional methods often lack specificity and require significant time and labor.

MALDI-TOF MS has emerged as a powerful technique for bacterial identification, however preparing samples for this method can be a bottleneck. In this application note, CTC Analytics investigates automated bacterial sample preparation for MALDI-TOF MS using the PAL System robotic platform, with the aim of streamlining workflows and boosting reliability.

PAL RTC

CTC Analytics AG

The PAL RTC with robotic tool change maximizes productivity in analytical and clinical labs.

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MALDI-TOF MSMALDI-TOF mass spectrometers (matrix-assisted laser desorption/ionization time-of-flight) are used for the mass analysis of large molecules, including proteins, DNA, polymers and other macromolecules due to its relatively soft ionization, reducing fragmentation whilst allowing fast data acquisition. Tandem mass analyzers such as TOF/TOF systems can be used to increase resolution and sensitivity of your analysis. Find the best MALDI-TOF products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Bacterial IdentificationInfectious DiseasesInfectious diseases are caused by pathogens such as bacteria, viruses, and fungi. Effective detection, prevention, and treatment are crucial to control outbreaks and improve public health. Diagnostic tools, vaccines, and antimicrobial treatments are essential components of managing these diseases. Research into emerging pathogens and resistance patterns continues to evolve. Browse our peer-reviewed product directory to find the best diagnostic tools, prevention solutions, and treatment options; compare products, read customer reviews, and get pricing directly from manufacturers.
Automated MALDI-TOF MS workflows for streamlined bacterial identification