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Faster Sample Filtration for HPLC with a Vacuum-Driven Multi-Sample Device

Merck
7 May 2017

Sample prefiltration is an important process that removes contaminants from samples for High Performance Liquid Chromatography (HPLC) prior to analysis. This application note describes the development of the Samplicity® G2 Filtration system to reduce hands-on time associated with preparing multiple samples and provide a simple, ergonomic workflow. It details data which shows that the Samplicity® G2 Filtration system gives a time saving of least 28% when preparing eight samples.

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Samplicity® filtration system

Merck

Introducing a vacuum filtration system that makes sample preparation easy: the EMD Millipore Samplicity filtration system with Millex Samplicity membrane filters. With the Samplicity® filtration system and Millex Samplicity® membrane filters, EMD Millipore has transformed sample preparation forever. Advantages of the EMD Millipore Samplicity filtration system include:   •  Higher throughput with simultaneous vacuum filtration of up to eight samples   •  Ergonomic alternative to syringe filters   •  Easy sample preparation of even highly viscous or particulate-laden mixtures   •  Millex Samplicity membrane filters provide long-trusted quality with low extractables and low analyte binding   •  Choose the unit color to fit your lab—bold blue or glossy green Applications of the EMD Millipore Samplicity filtration system include sample preparation for:   •  Dissolution testing   •  High-pressure liquid chromatography (HPLC)   •  Ultra-high performance liquid chromatography (UHPLC or UPLC®)  •  Liquid chromatography – mass spectrometry (LCMS)

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.FiltrationFiltration and microfiltration are used to separate solids, particulates or large molecules from fluids (liquid or gases) in order to purify the filtrate. Explore a range of filter formats, including filter paper, plates and membranes for your separation needs. While larger particulates may be separated by gravity filtration, smaller particulates may require additional force for timely separation. Microfiltration equipment includes vacuum filters, as well as positive pressure, crossflow and centrifugal filtration devices. Find the best filtration products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Sample PreparationSample preparation can improve the quality and speed of separation techniques. Products to assist sample preparation include filtration equipment, evaporators, membranes and sieves.HPLC Method DevelopmentIt is important to develop and validate HPLC methods in order to identify, quantify or purify compounds of interest in the most efficient way. Effective method development ensures optimization, quality control and cost effectiveness.Multi-Sample FiltrationErgonomicsVacuum Filtration

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Faster Sample Filtration for HPLC with a Vacuum-Driven Multi-Sample Device