Evaluation of the performance of a total workflow approach for the analysis of perand polyfluoroalkyl substances (PFAS) in fish, using an interlaboratory study
11 Jun 2023Due to rising concerns about the long-term impacts of per- and polyfluoroalkyl substances (PFAS) on human health, many agencies across the globe have been studying the occurrence of PFAS in food. Waters™ previously developed a method for the determination of PFAS in complex food commodities such as fish, meat, edible offal, and eggs which requires a comprehensive sample extraction and clean-up. This application brief shows the successful evaluation of the performance of this method by interlaboratory study. It is based upon an alkaline extraction, sample clean-up using Oasis™ WAX for PFAS Analysis SPE cartridge and determination using ACQUITY™ UPLC™ System fitted with the PFAS Analysis Kit, Isolator Column and Xevo™ TQ-XS Tandem Quadrupole Mass Spectrometer. A reference material of fish containing PFHxS, PFOS, PFOA, and PFNA was sent to seven Waters laboratories, along with standard solutions containing native PFAS compounds and isotopically labelled analogues. For the four PFAS analytes, trueness of the method was determined to be within the range of 102 to 121%. Repeatability within laboratories was <20% and between laboratory reproducibility ≤30%.
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Oasis™ WAX for PFAS Analysis
WatersExtraction and concentration without the low background contamination. Per- and polyfluoroalkyl substances (PFAS) are a growing global concern. Now your lab can extract and concentrate PFAS without worrying about low background contamination through the power of Oasis WAX for PFAS Analysis, a comprehensive quality-control pre-screening test for 32 PFAS.
ACQUITY UPLC System
WatersWaters ACQUITY UPLC - Dramatic Improvements in Speed, Sensitivity and Resolution Whether you work in methods development or quality assurance, in drug discovery and development or testing for safety in food supplies, you seek a productivity edge. With the ACQUITY UPLC® System, now you can get more information in a single, short run than you've ever seen with HPLC. Waters ACQUITY UPLC System UltraPerformance LC® (UPLC®) technology starts with unique 1.7 μm small-particle chemistries. Chromatographers no longer need to choose between speed and resolution–with UPLC you get both. Instrument Designed for Chemistry; Chemistry Designed for the Instrument The ACQUITY UPLC System has been holistically designed to match the performance needs of our innovative column chemistries with robust hardware, easy-to-use software and specialized support services. Small, pressure-tolerant particles High-pressure fluidic modules Minimized system volume Negligible carryover Reduced cycle times Fast response detectors Integrated system software and diagnostics With UPLC you have the ability to work more efficiently with higher speed, sensitivity and resolution at a much wider range of linear velocities, flow rates and backpressures to obtain superior results. The Waters ACQUITY UPLC System's high-pressure fluidics optimizes flow rates to make the most of small particle technology. The ACQUITY UPLC System's sample-handling design is designed to ensure exceptionally low carryover and reduced cycle time. And when interfaced with the Sample Organizer, it increases unattended sample capacity by ten times. High-speed detectors, both optical and mass, contribute to increased sensitivity and help manage the heightened speed and resolution requirements of UPLC. ACQUITY UPLC Systems are easily controlled, diagnosed, and monitored via a graphical system console interface. The console offers: Quick and easy access to critical instrument parameters Simple system start-up, elegant system status monitoring and predictive performance indicators to ensure maximum productivity Data management capabilities that are supported by both MassLynx™ and Empower™ software The ACQUITY UPLC System is also supported by Intelligent Device Management technology with our Connections® INSIGHT™ service, providing instrument diagnostics.