eCiphrNeuro: A High Throughput Assay to Detect Neurotoxic Compounds in Early Drug Discovery

Assessment of Neuronal Activity Using Microelectrode Array. The eCiphrNeuro assay uses primary cultures of rat cortical neurons. Cyprotex’s neuronal assay uses high throughput microelectrode array (MEA) technology to monitor electrophysiological activity. Neurons grown on microelectrode arrays recapitulate many features of neurons in vivo, including spontaneous activity (spiking and bursting), plasticity, organisation and responsiveness to a wide range of neurotransmitters and pharmacological agonists/antagonists. This technology provides a unique in vitro system for preclinical drug discovery, neurotoxicity assessment and disease modelling.