Determining Residue on Ignition in Pharmaceutical and Nutraceutical Products by Gravimetric Loss on Ignition Analysis
3 Dec 2014Pharmaceutical and Nutraceutical companies have a responsibility to ensure the drugs they are distributing are not only safe and effective for the consumers but are consistent between different batches and manufactures; this involves measuring the residue on ignition (ROI). The % ROI describes the amount of total concentration of inorganic salts and trace metals that fail to ignite at 600 °C. In this application note, Arizona Instrument was able to demonstrate equivalency between the traditional muffle furnace method and the Computrac® MAX® 5000XL Moisture and Ash Analyzer for several vitamins and supplements.
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Computrac® MAX® 5000XL
Arizona Instrument LLCComputrac® MAX® 5000XL - Moisture, Solids & Ash Analyzer Rapid loss-on-drying instrumentation has proven to provide a more desirable method of moisture measurement when compared to traditional loss-on-drying techniques. The ease of use and reduction in test times increases manufacturing efficiency while simultaneously reducing energy costs.Computrac® MAX® 5000XL Features: Temperature Calibration Interface (TCI) Module (optional) 21 CFR Part 11 Compliant (optional) Accuracy, Durability, Reliability, Consistency and Speed Four Decimal Place Balance Parameter Expert (develop parameters to match reference method) Programmable Temperature Ramp Control Linked Test Capability for Multiple Results from a Single Sample Security Access Codes to Protect Programs or Instrument Settings Customizable Test Parameters to Optimize Results Real-Time Graphing of Weight Loss, Rate and End Point Prediction Foil and Syringe Weight Entry Mode for the Most Volatile Samples Weight Control Aids Operators and Improves Test Precision Statistical Function Calculates Mean, Standard Deviation and Relative Standard Deviation Alphanumeric Programmable Prompts for Sample ID and Lot Numbers Self Cleaning Oven Simplifies Routine Maintenance Ethernet and Serial Ports, USB Web Server (optional)