Determination of genotoxic nitrosamine impurity in Bumetanide API and tablets

24 Mar 2021

In this application note, discover an LC/MS/MS based method designed to overcome the challenges faced when undertaking quantitative analysis of N-nitroso Bumetanide impurity in Bumetanide API and low dose tablets.

Agilent 1290 Infinity II LC System

Agilent Technologies

The 1290 Infinity II LC System is an ultra-high performance LC that has market-leading sample capacity and is designed for the lowest dispersion for the most challenging ultra-HPLC experiments. The 1290 Infinity II LC system is designed to be both a HPLC and high-end UHPLC system in a single flow path, giving you robust and excellent performance no matter what application you are running while seamlessly integrating into your existing laboratory environment.

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Determination of genotoxic nitrosamine impurity in Bumetanide API and tablets