Decoding neurological disease through proteomics

13 Oct 2026

This application eBook explores how high-plex proteomics is advancing the study of neurological diseases, from Parkinson’s and Alzheimer’s disease to dementia and age-related cognitive decline. Discover how large-scale protein analysis of cerebrospinal fluid and blood samples can reveal disease-associated pathways, identify potential biomarkers and support therapeutic target discovery. Explore real-world research examples involving longitudinal cohort studies, multiomic integration, machine learning and the Global Neurodegeneration Proteomics Consortium (GNPC), highlighting how proteomics is helping researchers uncover the complex biology underlying neurodegeneration and neurological aging.

Resource details:

Resource type: Application eBook
Page count: 21
Read time: 25 mins

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ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :NeurodegenerationNeurodegeneration refers to the progressive deterioration of the structure and function of the nervous system, often seen in diseases like Alzheimer's and Parkinson's. Research focuses on early detection and potential therapies. Explore neurodegeneration research tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.