Current methodologies for drugs of abuse whole blood testing

19 Aug 2025

Extraction of drugs of abuse panels from whole blood samples can be challenging, especially when analyzing a broad panel of analytes from different classes. This white paper studies the analysis of 56 common illicit drugs in whole blood, focusing on various aspects of sample preparation, including pre-treatment of whole blood samples, extraction techniques, and automation using Biotage® Extrahera sample preparation workstation.

Biotage® Extrahera™ Automated Extraction System

Biotage

Biotage® Extrahera™ is an automated positive pressure workstation for column-based sample preparation in food and environmental testing. Supporting PFAS, pesticides, PCBs, PAHs, mycotoxins, and more, it handles 2 µL–50 mL volumes in plates or columns with dual-flow processing, precise pipetting, and GLP compatibility for reproducible, high-throughput results.

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Current methodologies for drugs of abuse whole blood testing