Correlation of Complex Signaling Pathway Interactions with Cell Migration in a Combined Cell Migration-Phosphorylation Assay

This scientific poster from LI-COR Biosciences presents a screening assay that allows simultaneous assessment of cell migration and kinase activity. It is shown that the Oris Cell Migration Assay platform can be successfully used in combination with LI-COR Odyssey and Aerius instruments to obtain multiplexed data on the inhibition of cell migration by different classes of compounds, as well as their effects on intracellular signaling pathway events using the In-Cell Western technique. A better understanding of the mechanisms underlying cell movement and metastasis may facilitate a more efficient means of developing anti-cancer drugs.