CoraFluor TR-FRET assay screens for modulators of STUB1 – HSP70 interaction

Protein-protein interactions play a critical role in drug discovery, but developing assays that are both sensitive and robust enough for high-throughput screening can be challenging. Researchers studying the STUB1 (CHIP)-HSP70 pathway need reliable tools to identify modulators efficiently while maintaining confidence in assay performance and reproducibility.

Explore how the CoraFluor™ TR-FRET Assay enables screening for modulators of the STUB1-HSP70 interaction using a streamlined, homogeneous assay format. Discover how it delivers an assay window of approximately 50% and an impressive Z′ factor of 0.92, supporting high-throughput screening (HTS) and structure-activity relationship (SAR) workflows. Gain insights into a robust approach that can help accelerate hit discovery and advance drug development with greater confidence.

Resource details:

Resource type: Application note
Page count: 2
Read time: 4 mins