Efficient chromatin removal in viral vector manufacturing using salt-active nucleases

The presence of chromatin-associated DNA in crude viral suspensions poses significant challenges for the downstream processing (DSP) of viral vectors. Peer-reviewed studies have demonstrated that M-SAN HQ excels in removing chromatin-associated DNA at physiological salt conditions, significantly outperforming traditional nucleases like Benzonase^® and Denarase^®. Explore how, together with SAN HQ for high salt conditions, ArcticZymes offers solutions specifically designed to meet the distinct needs of biomanufacturers.