Bioconjugation resource guide

26 Feb 2026

Bioconjugation enables researchers to link biomolecules for applications ranging from immunoassays to imaging, yet achieving stable, efficient, and reproducible conjugates can be challenging. Variability in linker chemistry, reaction conditions, and purification steps often leads to inconsistent performance, making it difficult for scientists to generate high‑quality conjugates without specialist expertise. Vector Laboratories’ SoluLINK® technology addresses these issues with quantifiable, aqueous‑compatible chemistry designed for reliability across proteins, antibodies, oligonucleotides, and beads.

This guide covers the principles, workflows, and advantages of SoluLINK bioconjugation, and explores how to select the right approach, troubleshoot key steps, and produce stable, high‑purity conjugates with confidence. It offers practical guidance that supports more consistent labeling, streamlined assay development, and improved experimental outcomes across diverse applications.

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OligonucleotidesOligonucleotides are small nucleic acid polymers, usually less than 20 bases in length. Oligonucleotides can be made via enzymatic cleavage or more commonly by chemical synthesis with polymerases. Their use includes FISH, southern blots, microarrays and as primers in PCR. High fidelity synthesis kits and detection systems are available for easy production and detection, respectively.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.
Bioconjugation resource guide