ResourceLife Sciences
Assessing Drug Sensitivity and Effects in Complex 3D Tumor Models
13 Feb 2014Cell viability assays are commonly used in drug discovery to characterize cell responses to endogenous and exogenous factors or substances. However, fluorescence-based cellular assays are becoming increasingly popular, due to their sensitivity and versatility. This application note demonstrates how the combining Tecan’s Infinite M200 PRO with the InSphero’s organotypic microtissue tumor model (which harbors fluorescent reporter proteins) provides a scalable system to assess drug sensitivity in complex 3D cell culture models. The results show that this combination provides a powerful tool to assess drug sensitivity in more complex 3D cell culture models.
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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.CytotoxicityCytotoxicity assays measure the toxic effects of substances on cells, often used in drug testing and environmental studies. These tests are crucial in determining the safety of chemicals and pharmaceutical compounds. Explore cytotoxicity testing tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Drug DevelopmentDrug development refers to the process of bringing a new drug to market.
