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Analysis of Drugs of Abuse by GC/MS Using Ultra Inert Universal Sintered Frit Liners

14 Jul 2019

Gas chromatography/mass spectrometry (GC/MS) is a common screening technique for controlled substance analyses. Maintaining an inert flowpath is important in these analyses to prevent loss of peak shape and signal of the more sensitive or active compounds, such as amphetamine or oxycodone. In this application note, Agilent discusses how a sintered frit liner offers the same protection from complex nonvolatile matrices as glass wool liners, while avoiding wool breakage that may cause loss of peak response.

GC/MS Forensic Toxicology Analyzer 

Agilent Technologies

GC/MS methods are widely used for forensic toxicology, especially for the screening of large numbers of target compounds in complex matrices. Full-scan EI methods offer many advantages for broad-range screening, such as an unlimited number of targets, full-spectrum identity confirmation, and library searching for identification of non-targets. Technologies such as Capillary Flow Technology backflushing, Deconvolution Reporting Software (DRS), and a toxicology library offer opportunities to increase the number of targets screened while reducing the time required per sample. Agilent GC/MS analyzers are ready to use and simplify startup. The analysis method makes use of the latest GC/MS technologies, improving productivity in the laboratory and producing consistent, high-quality data from day one.

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