Analysis of Antibody Drug Conjugates (ADCs) by Native Mass Spectrometry on the BioAccord System
16 May 2019Here Waters Corporation demonstrate the performance of the BioAccord™ System for the analysis of antibody drug conjugates (ADCs) under native conditions.
The BioAccord System is a small footprint, high performance bench top system that was designed and developed with simplified user interface as well as automatic system setup and self-diagnostic capabilities.
The obtained result shows that BioAccord System is well suited for routine LC(SEC)-native MS analysis of both cysteine and lysine conjugated ADCs. The average DARs and drug loading distribution results were comparable to that generated from Hydrophobic Interaction Chromatography (HIC) separation (with TUV detection), and results from previous generations of QTof MS systems. Simplified system operation and configurable compliance features will enable the BioAccord System to be readily adopted by scientists with less MS experience, which will allow organizations to more readily deploy the mass spectrometry in supporting ADC across development and manufacturing processes.
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BioAccord LC-MS System
WatersThe First SmartMS-Enabled Biopharma Solution The Waters BioAccord System is an integrated system that simplifies high performance LC-MS biopharmaceutical analysis for every user. An easy-to-use system solution that puts the power to make decisions directly in your hands; a self-calibrating, self-optimizing, self-sufficient tool that equips you with high quality data you can use to tackle the challenges you face every day during biopharmaceutical development.