A robust method for comprehensive metabolomic profiling of dried blood spots, serum, and plasma

Compared to traditional blood collection methods, dried blood spots (DBS) offer a minimally invasive and efficient alternative for metabolic profiling. GC/MS is a widely utilized analytical platform in metabolomics; however, many metabolites are not stable enough for direct analysis.

In this application note, CTA Analytics details a fully automated, in-vial derivatization method for GC/MS analysis of DBS, serum, and plasma samples, focusing on its application to untargeted metabolomic analysis.