ResourceLife Sciences
A robust method for comprehensive metabolomic profiling of dried blood spots, serum, and plasma
26 Feb 2026Compared to traditional blood collection methods, dried blood spots (DBS) offer a minimally invasive and efficient alternative for metabolic profiling. GC/MS is a widely utilized analytical platform in metabolomics; however, many metabolites are not stable enough for direct analysis.
In this application note, CTA Analytics details a fully automated, in-vial derivatization method for GC/MS analysis of DBS, serum, and plasma samples, focusing on its application to untargeted metabolomic analysis.
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GC-MS GC-MS (gas chromatography-mass spectrometry) instruments and equipment are used to separate, quantify and identify mixtures of small and volatile compounds, such as polycyclic aromatics, fatty acids and alcohols. Often used in drug detection, forensic investigation and environmental analysis for pesticides and contaminants, GC-MS is a powerful addition to your lab’s analytical capabilities. GC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzers can give greater sensitivity and resolution to your analysis. Find the best GC-MS instruments and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Metabolites From BloodMetabolite Profiling