A Novel Three-Dimensional Immune Oncology Model for High Throughput Testing of Tumoricidal Capability
17 May 2017There has been increasing interest in utilizing immune cells for cancer treatment, with therapy involving activating a patient’s own T-cells to attack their tumors. This study demonstrates that the combination of the Corning spheroid microplates and the HTS Transwell 96-well permeable supports allows for a novel 3D model that combines immune cell migration, effector-induced cytotoxicity, and immune cell evasion in one easy to use model.
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Corning® 96-well Black/Clear Round Bottom Ultra-Low Attachment Surface Spheroid Microplate, Bulk Packed, with Lid, Sterile, 10/Bag
Corning Life SciencesUltra-low attachment surface with covalently bonded hydrogel that minimizes cell attachment, protein absorption, enzyme activation and cellular activation The surface is noncytotoxic, biologically inert and nondegradable Round bottoms with 300 µL total volume Recommended working volumes of 0.075 to 0.30 mL Sterilized by gamma radiation Novel well geometry aids formation of spheroids in center of well Optically clear round bottom with black opaque microplate body