Tackling forever chemicals: A fully automated workflow for high-throughput analysis of volatile PFAS in food contact materials

26 Feb 2026

The unique properties of per- and polyfluoroalkyl substances (PFAS) have led to their widespread use in consumer products, such as paper-based food contact materials (FCMs), like fast-food wrappers. However, it has been well-established that PFAS migrate from packaging into food, creating a direct pathway for human dietary exposure and posing potential health risks. There is a growing need for sensitive and reliable analytical methods for PFAS analysis, however, there are a number of challenges associated with this, such as sample preparation bottlenecks.

In this application note, CTC Analytics presents a fully automated workflow that handles everything from initial sample extraction to final injection, developing and validating a complete workflow for analyzing volatile PFAS in common FCMs.

PAL RTC

CTC Analytics AG

The PAL RTC with robotic tool change maximizes productivity in analytical and clinical labs.

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GC-MS GC-MS (gas chromatography-mass spectrometry) instruments and equipment are used to separate, quantify and identify mixtures of small and volatile compounds, such as polycyclic aromatics, fatty acids and alcohols. Often used in drug detection, forensic investigation and environmental analysis for pesticides and contaminants, GC-MS is a powerful addition to your lab’s analytical capabilities. GC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzers can give greater sensitivity and resolution to your analysis. Find the best GC-MS instruments and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Solid-Phase ExtractionSolid-phase extraction (SPE) is used for clean-up, extraction and concentration of semi-volatile or non-volatile analytes from complex mixtures including blood, urine and food samples. Multiple formats are available for conducting SPE, including prepacked SPE cartridges, disks and microplates, as well as SPE sorbent powders for manual packing. SPE systems can be used to automate the process and extract multiple samples at once. Solid-phase microextraction (SPME) and supported liquid extraction (SLE) products are also available in the same formats. Find the best SPE, SLE and SPME equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.AutomationAutomation in laboratories and manufacturing processes enhances efficiency, precision, and scalability by reducing the need for manual intervention. It plays a critical role in improving productivity, minimizing human error, and accelerating workflows in fields like diagnostics, drug development, and industrial testing. Automation technologies include robotic systems, automated liquid handlers, and process control systems that streamline complex tasks and ensure consistent, reproducible results. Explore our peer-reviewed product directory to discover the best automation solutions, compare options, read user reviews, and get prices directly from manufacturers.PFAS