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A comparison of HRAM Orbitrap and MS/MS for anaylsis of polyfluoroalkyl substances by EPA Method 537

26 Feb 2020

In this application note, Thermo Fisher Scientific demonstrates liquid chromatography - high-resolution, accurate-mass (LC-HRAM) methodology using Orbitrap™ technology as a sensitive, accurate and reliable quantitative alternative to the use of triple quadruple mass spectrometers, while stimultaneously determining unknown perfluorinated compounds in the same drinking water extracts.

Thermo Scientific™ UltiMate™ 3000 UHPLC system

Thermo Fisher Scientific

  The Thermo Scientific™ UltiMate™ 3000 HPLC system offers UHPLC compatibility across all modules, ensuring maximum performance. Covering flows from 20 nL/min to 10 mL/min and offering a wide range of pumping, sampling, and detection modules, the UltiMate 3000 series provides solutions for all your chromatography needs. UltiMate 3000 HPLC system Features & Benefits:   UHPLC design for all nano, standard analytical, and RSLC systems. 620 bar maximum pressure for basic and standard analytical systems—setting a new benchmark in HPLC. x2 Dual Systems form a unique platform for routine analysis, increased productivity solutions, and advanced chromatographic techniques. Systems are controlled using Thermo Scientific™ Chromeleon™ Chromatography Data System software—providing Intelligent Functionality and Operational Simplicity™. Systems are offered with Thermo Scientific™ Viper™ and Thermo Scientific™ nanoViper™ fitting systems—fingertight, zero-dead-volume connections even at UHPLC pressures.

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A comparison of HRAM Orbitrap and MS/MS for anaylsis of polyfluoroalkyl substances by EPA Method 537