Assay Assembly Reagents
R&D Systems Recombinant SCF Protein Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28 - 40 kDa type I transmembrane glycoprotein. It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors. Specifications and Use for R&D SC…
SIRT1 belongs to the class III family of HDACs, which are NAD+ dependent enzymes. SIRT1 modulators have been shown to play a beneficial role in treating diseases such as cancer, diabetes, metabolic disease and inflammation, making them attractive targets for the development of new drugs. The new HTRF® SIRT1 assay, developed by Cisbio Bioassays using its patented HTRF technology, is a homogeneous method for directly measuring S…
G-Protein Coupled Receptors (GPCRs) are common drug targets. Previously, most studies were based on the monomeric model, but this perception of GPCRs is now evolving towards homodimeric , heterodimeric and oligomeric models. To facilitate research into GPCR dimers, CisBio Bioassays has applied the Tag-lite® technology to GPCR interaction assays. Based on HTRF® technology, plasmids have been designed to express either the SNA…
Cisbio Bioassays offer a comprehensive cellular platform to develop HTRF® ligand binding assays.Features: • Single technology and cellular platform for all GPCR assays • Unique non-radioactive ligand binding assays • Miniaturization down to < 10µl • Peptidic and non-peptidic fluorescent ligands • High Specific Binding • Low Non-Specific Binding with HTRF technology Tag-lite fluorescent ligands available for (Feb10): Vasopre…
Tag-lite® cell-lines and reagents, a multimodal environment streamlined for GPCR studies. Cellular trans-membrane receptors are high potential therapeutic targets in pharmacological research, among them G-Protein Coupled Receptors (GPCRs). To reach a better physiological understanding, their study is deepening and is now focusing on structural assessments (ligand binding, dimerisation) and also on multiple signal pathway assa…
