Electrophysiology is the study of biological voltage changes, from a single ion channel through to a whole organ scale. Voltages can be measured using patch clamping, automated workstations, electrophysiology rigs or cell based assays. Specific cell lines, manipulators and microinjectors are also available for electrophysiology research.
Brief pulses of electricity are used in various biomedical research applications as a stimulus to excite nerve or muscle fibers. Several factors need to be considered when choosing the right stimulator.The DS2A Mk.II provides a precise Constant Voltage stimulus (up to 100V) controllable in Pulse Duration and Amplitude from self-contained batteries, making it ideally suited to electrophysiological recording in small preparation…
Brief pulses of electricity are used in various biomedical research applications as a stimulus to excite nerve or muscle fibers. Several factors need to be considered when choosing the right stimulator.The DS3 provides a precise Constant Current stimulus (up to 32mA) controllable in Pulse Duration and Amplitude and as with the DS2A this output comes from self-contained batteries. The DS3 also features a "clamp" or discharge c…
The DS4 takes an analogue voltage waveform defined within your own data acquisition/ control system and converts it into an isolated constant current stimulus. The DS4 will accept several input voltage ranges and produces four output ranges (±10µA, ±100µA, ±1mA and ±10mA). It also features a GATE input, so that several DS4 units can be controlled by a single analog waveform, but enabled individually via this GATE input. A t…
The ITC-18 is the second-generation low-noise 16-bit computer interface from Instrutech Corporation. The ITC-18 offers unsurpassed capability while retaining all of the exceptional features of its predecessor, the ITC-16. The ITC-18 provides a major improvement in the quality of acquired data, making measurements that would otherwise not be possible.* All synchronous analog and digital channels are optically isolated* Eight si…
The world's smallest patch clamp rig. Providing biggest results. The Port-a-Patch is a one-cell-at-a-time system, which is surprisingly small for a complete patch clamp rig. Patch clamp recordings in the whole cell configuration, and single channel recordings in the cell attached configuration, can be performed with planar patch clamp chips. The Port-a-Patch is routinely provided with an Axon/MDC MultiClamp amplifier or an EPC…
• straightforward preparation of GUVs • growth of GUVs can be monitored via microscope • GUVs can be used for solvent free bilayer recordings with Nanion's Port-a-Patch or Patchliner The Nanion Vesicle Prep Pro is a stand-alone workstation for the preparation of giant unilamellar vesicles (GUVs). To form the GUVs, the principle of electro-swelling is used. Lipid is spread on the glass substrate of the vesicle chamber, so that…
Run dual two-electrode voltage clamp experiments simultaneously:With two additional micromanipulators, the system can perform dual two-electrode voltage clamp (TEVC) experiments simultaneously. Designed to be affordable to the scientific community, this system increases productivity significantly. Additional units can be run in parallel to further increase TEVC throughput.Run up to four patch clamp simultaneously:As each man…
The ez-gSEAL 100A pressure controller is designed mainly for automated patch clamping, but it can also be used for many other applications. With the ez-gSEAL pressure controller, patch clamping becomes as easy as a click of a button. You may use it with our ezPATCH 100A smart manipulator, PatchMAX 100A automated patch clamp system, ChannelMAX 100A Mini automated dual clamp system or ChannelMAX 100A Twin automated quad clamp sy…
Incredibly small footprint:This patent-pending design has an 8" x 8" footprint; it is the smallest multifunction patch clamp system available. The automated patch clamping system replaces the microscope and the manipulator in the traditional rig. Complete with one automated manipulator, a manual XY stage, a data acquisition board & control system, and a perfusion chamber with the platform, this system can automatically guide…
The NL900D Case & Power Supply unit forms the heart of every NeuroLog System. Modules are not only powered by this unit, but wiring within the case allows signals to be passed between modules without the need for a mass of cable connections through the front panel sockets. The NL900D measures 133mm (high), 483mm (wide) and 317mm (deep).
* Small working volume (* Fast solution exchangeExpression of recombinant receptors in oocytes has been a favorite choice for researchers to assess the pharmacology of recombinant receptors. Since the oocytes are 1-1.5 mm in diameter, however, fast solution exchange around the oocyte was difficult. After several years of electrophysiological research, we have designed a Xenopus oocyte perfusion chamber for use in automated and…
Perfusion chamber, holds 35mm & 50mm Petri dishes (Corning Brand ONLY), or 25mm x 75mm glass slides
* Perfuse cells right in your 35mm Nunc Petri Dish (our default size)Cells cultured in Petri dishes are a popular research tool used in numerous applications, including patch clamping and intracellular ion probe imaging. True perfusion (continuous inflow and outflow) of solutions can be difficult to configure. This forces scientists to plate cells on cover slips for placement into specially designed perfusion chambers. However…
The BSC1 chamber design is similar to the original "Oslo chamber" (Langmoen & Andersen 1981) with later modifications (Dhanjal & Sears 1980, Alger et al, 1984) to allow both interface and submerged methods of slice maintenance.* "Submerged" and "Interface" methods of slice maintenance with same chamber This chamber allows adaptation to either method of slice maintenance simply by altering the fluid level by means of a screw ad…
* "Interface" method of slice maintenance* Dual feed channels for perfusion solution* Use entire surface for multiple slices or templates* Single and dual well templates, other designs available upon request* Single well template has provision for temperature probe and ground wire* Proportional temperature controller (PTC03) with low noise performance used for heating - available separatelyThis slice recording chamber is desig…
This item is the HOLDER (BSKH) and Brain Slice Keeper (S-BSK). * Slices maintained for many hours prior to transfer to recording chamber* Simple to set up and maintain * Slices supported on a quick-change nylon net The Brain Slice Keeper has been designed to pre-incubate brain slices prior to transfer into recording chambers. It consists of a pair of closely fitting acrylic rings, upper and lower, between which is wedged a she…
The MS1 chamber has been designed for use with fixed-stage upright-type microscopes. The particular feature of this chamber is the profiled contour that allows the microscope objective to sweep across the preparation when changing magnification, without having to adjust the focusing. In this way the specimen and any pre-positioned microelectrodes remain par-focal. This is particularly useful for confocal microscopy where it is…
The PC series perfusion chambers have embedded magnets that are conveniently located to retain perfusion plumbing and ground plugs. They are designed to fit into our 8090c fixed stage platform. A standard 22 mm cover slip is used to create the chamber bottom that is attached with vacuum grease, silicon, or parafilm (use a heat gun to gently melt the parafilm). There are two plastic retention screws for added security. Both ope…
The piezo solution switcher uses a high-speed piezo flexure guided nanopositioner to move pipette tips in solution switching applications. It can move an electrode tip across a 5 µm thick theta glass septum. This system is ideal for measuring cellular response to drugs or other elements in solution. Piezo movement can be triggered by either input from common recording amplifier equipment or by Siskiyou software via a LabVIEW™…
The Lambda 10-2 is a microprocessor controlled, high speed filter wheel. Its impressive speed coupled with exceptionally smooth operation make the Lambda 10-2 ideal for research applications involving fluorescence microscopy, ratio imaging, spectrophotometry, visual physiology, or any application requiring rapid and accurate aperture positioning.The Lambda 10-2 controller which has both serial and parallel interfaces will driv…
The Manual Injector is a manual syringe driver for pneumatic or hydraulic control of injection needles or holding pipettes. It is suitable for injecting volumes in the nanoliter to microliter range. It is also widely used as a fluid control device for IVF applications requiring sensitive manual control of the displacement of microneedle contents. The system is constructed from the highest quality parts. The base assembly is bl…
This motorized micromanipulator with a rack mount controller unit is affordable yet offers advanced features found in manipulators costing thousands more. Custom engineered stepping motors, precision cross-roller bearing slides and proprietary worm gear capstan drives form the basis of the watch-like mechanical system. The controller provides power to the stage motors with a quiet linear power supply to minimize electrical noi…
The MP-265/M "narrow format" mechanical is designed especially for patch-slice manipulator systems that require more than 2 or 3 pipettes. Coupled with our multi-manipulator controller, MPC-200, users have the ability to easily build up multi-manipulator MPC-365 systems for positioning multiple recording and stimulating pipettes.Resolution: Minimal microstep size is 62.5 nanometers per microstep. Display has single micron reso…
The flagship in Sutter's line of precision micromanipulators, the motorized MP-285 is affordable yet offers advanced features found in manipulators costing thousands more. Custom engineered stepping motors, precision cross-roller bearing slides and proprietary worm gear capstan drives form the basis of the watch-like mechanical system. The controller provides power to the stage motors with a quiet linear power supply to minimi…
Developed through years of experience with the Flaming/Brown style micropipette pullers and infused with leading edge technology, Sutter is proud to introduce the P-1000 micropipette puller. The most obvious new feature is the color touchscreen display that provides an intuitive and full-featured interface. F E A T U R E S > P - 1 0 0 0Color touch-screen interfaceSafe heat mode to protect and extend filament lifePipette Cookbo…
