Electrophysiology is the study of biological voltage changes, from a single ion channel through to a whole organ scale. Voltages can be measured using patch clamping, automated workstations, electrophysiology rigs or cell based assays. Specific cell lines, manipulators and microinjectors are also available for electrophysiology research.
• straightforward preparation of GUVs • growth of GUVs can be monitored via microscope • GUVs can be used for solvent free bilayer recordings with Nanion's Port-a-Patch or Patchliner The Nanion Vesicle Prep Pro is a stand-alone workstation for the preparation of giant unilamellar vesicles (GUVs). To form the GUVs, the principle of electro-swelling is used. Lipid is spread on the glass substrate of the vesicle chamber, so that…
Run dual two-electrode voltage clamp experiments simultaneously:With two additional micromanipulators, the system can perform dual two-electrode voltage clamp (TEVC) experiments simultaneously. Designed to be affordable to the scientific community, this system increases productivity significantly. Additional units can be run in parallel to further increase TEVC throughput.Run up to four patch clamp simultaneously:As each man…
The ez-gSEAL 100A pressure controller is designed mainly for automated patch clamping, but it can also be used for many other applications. With the ez-gSEAL pressure controller, patch clamping becomes as easy as a click of a button. You may use it with our ezPATCH 100A smart manipulator, PatchMAX 100A automated patch clamp system, ChannelMAX 100A Mini automated dual clamp system or ChannelMAX 100A Twin automated quad clamp sy…
Incredibly small footprint:This patent-pending design has an 8" x 8" footprint; it is the smallest multifunction patch clamp system available. The automated patch clamping system replaces the microscope and the manipulator in the traditional rig. Complete with one automated manipulator, a manual XY stage, a data acquisition board & control system, and a perfusion chamber with the platform, this system can automatically guide…
The NL900D Case & Power Supply unit forms the heart of every NeuroLog System. Modules are not only powered by this unit, but wiring within the case allows signals to be passed between modules without the need for a mass of cable connections through the front panel sockets. The NL900D measures 133mm (high), 483mm (wide) and 317mm (deep).
* Small working volume (* Fast solution exchangeExpression of recombinant receptors in oocytes has been a favorite choice for researchers to assess the pharmacology of recombinant receptors. Since the oocytes are 1-1.5 mm in diameter, however, fast solution exchange around the oocyte was difficult. After several years of electrophysiological research, we have designed a Xenopus oocyte perfusion chamber for use in automated and…
Perfusion chamber, holds 35mm & 50mm Petri dishes (Corning Brand ONLY), or 25mm x 75mm glass slides
* Perfuse cells right in your 35mm Nunc Petri Dish (our default size)Cells cultured in Petri dishes are a popular research tool used in numerous applications, including patch clamping and intracellular ion probe imaging. True perfusion (continuous inflow and outflow) of solutions can be difficult to configure. This forces scientists to plate cells on cover slips for placement into specially designed perfusion chambers. However…
The BSC1 chamber design is similar to the original "Oslo chamber" (Langmoen & Andersen 1981) with later modifications (Dhanjal & Sears 1980, Alger et al, 1984) to allow both interface and submerged methods of slice maintenance.* "Submerged" and "Interface" methods of slice maintenance with same chamber This chamber allows adaptation to either method of slice maintenance simply by altering the fluid level by means of a screw ad…
* "Interface" method of slice maintenance* Dual feed channels for perfusion solution* Use entire surface for multiple slices or templates* Single and dual well templates, other designs available upon request* Single well template has provision for temperature probe and ground wire* Proportional temperature controller (PTC03) with low noise performance used for heating - available separatelyThis slice recording chamber is desig…
This item is the HOLDER (BSKH) and Brain Slice Keeper (S-BSK). * Slices maintained for many hours prior to transfer to recording chamber* Simple to set up and maintain * Slices supported on a quick-change nylon net The Brain Slice Keeper has been designed to pre-incubate brain slices prior to transfer into recording chambers. It consists of a pair of closely fitting acrylic rings, upper and lower, between which is wedged a she…
The MS1 chamber has been designed for use with fixed-stage upright-type microscopes. The particular feature of this chamber is the profiled contour that allows the microscope objective to sweep across the preparation when changing magnification, without having to adjust the focusing. In this way the specimen and any pre-positioned microelectrodes remain par-focal. This is particularly useful for confocal microscopy where it is…
The PC series perfusion chambers have embedded magnets that are conveniently located to retain perfusion plumbing and ground plugs. They are designed to fit into our 8090c fixed stage platform. A standard 22 mm cover slip is used to create the chamber bottom that is attached with vacuum grease, silicon, or parafilm (use a heat gun to gently melt the parafilm). There are two plastic retention screws for added security. Both ope…
The piezo solution switcher uses a high-speed piezo flexure guided nanopositioner to move pipette tips in solution switching applications. It can move an electrode tip across a 5 µm thick theta glass septum. This system is ideal for measuring cellular response to drugs or other elements in solution. Piezo movement can be triggered by either input from common recording amplifier equipment or by Siskiyou software via a LabVIEW™…
The Lambda 10-2 is a microprocessor controlled, high speed filter wheel. Its impressive speed coupled with exceptionally smooth operation make the Lambda 10-2 ideal for research applications involving fluorescence microscopy, ratio imaging, spectrophotometry, visual physiology, or any application requiring rapid and accurate aperture positioning.The Lambda 10-2 controller which has both serial and parallel interfaces will driv…
The Manual Injector is a manual syringe driver for pneumatic or hydraulic control of injection needles or holding pipettes. It is suitable for injecting volumes in the nanoliter to microliter range. It is also widely used as a fluid control device for IVF applications requiring sensitive manual control of the displacement of microneedle contents. The system is constructed from the highest quality parts. The base assembly is bl…
This motorized micromanipulator with a rack mount controller unit is affordable yet offers advanced features found in manipulators costing thousands more. Custom engineered stepping motors, precision cross-roller bearing slides and proprietary worm gear capstan drives form the basis of the watch-like mechanical system. The controller provides power to the stage motors with a quiet linear power supply to minimize electrical noi…
The MP-265/M "narrow format" mechanical is designed especially for patch-slice manipulator systems that require more than 2 or 3 pipettes. Coupled with our multi-manipulator controller, MPC-200, users have the ability to easily build up multi-manipulator MPC-365 systems for positioning multiple recording and stimulating pipettes.Resolution: Minimal microstep size is 62.5 nanometers per microstep. Display has single micron reso…
The flagship in Sutter's line of precision micromanipulators, the motorized MP-285 is affordable yet offers advanced features found in manipulators costing thousands more. Custom engineered stepping motors, precision cross-roller bearing slides and proprietary worm gear capstan drives form the basis of the watch-like mechanical system. The controller provides power to the stage motors with a quiet linear power supply to minimi…
Developed through years of experience with the Flaming/Brown style micropipette pullers and infused with leading edge technology, Sutter is proud to introduce the P-1000 micropipette puller. The most obvious new feature is the color touchscreen display that provides an intuitive and full-featured interface. F E A T U R E S > P - 1 0 0 0Color touch-screen interfaceSafe heat mode to protect and extend filament lifePipette Cookbo…
A significant advance in the technology of fabrication of micropipettes, optical fiber probes, and nanospray tips, is offered with the P-2000 micropipette puller. The P-2000 integrates a CO2 laser-based heat source with the technology derived from our extensive experience with conventional pullers. This system offers capabilities unmatched by other pullers. While the P-2000 is suitable for working with most conventional glasse…
The Model P-30 vertical micropipette puller is designed for the fabrication of basic micropipettes and patch-type pipettes. It will pull micropipettes with tip diameters as small as 0.3µm and moderate taper lengths (10 to 15mm). By using an included patching attachment, the P-30 will pull the standard double pull patch-type pipette. Used with thin wall glass capillaries, it will generate pipettes or needles suitable for microi…
The Model P-97 micropipette puller is the latest generation of the Flaming/ Brown type puller for fabrication of micropipettes, patch pipettes and microinjection needles. While retaining many of the features on the Model P-87, the P-97 offers improvements in mechanical, electronic and software design. The result is better control of the pulling process and a higher degree of reproducibility. The P-97 combines a proven mechanic…
TMC’s Active Vibration Isolation Table features state-of-the-art vibration isolation performance. By integrating our new Compact Sub-Hertz Pendulum Isolation System (CSP®) for horizontal vibration reduction with our new PEPS-VX® Inertial Damper for vertical vibration cancellation, we have produced a superior, ultra-quiet table in six degrees-of-freedom. This advanced isolation technology may be combined with TMC optical tables…
63-500 Series High-Performance Lab Air TableIsolator with 4 in. CleanTop II, 1/4-20 on 1 in. spacing 36 in. x 48in., 900x1200 mmFeatures: • Gimbal Piston™ Isolators• Thin-Wall Rolling Diaphragms • All-aluminum height control valves• Internal Piston Travel Restraints• Tiebar Gussets• Rugged Built in leveling feet• Superior Table TopsTMC 63-500 Series High-Performance Lab Tables provide an excellent vibration-free working surfac…
