Products, services, reviews and techniques used in the identification and validation of the disease-causing target genes and proteins.
Cisbio Bioassays offer a comprehensive cellular platform to develop HTRF® ligand binding assays.Features: • Single technology and cellular platform for all GPCR assays • Unique non-radioactive ligand binding assays • Miniaturization down to < 10µl • Peptidic and non-peptidic fluorescent ligands • High Specific Binding • Low Non-Specific Binding with HTRF technology Tag-lite fluorescent ligands available for (Feb10): Vasopre…
Tag-lite® cell-lines and reagents, a multimodal environment streamlined for GPCR studies. Cellular trans-membrane receptors are high potential therapeutic targets in pharmacological research, among them G-Protein Coupled Receptors (GPCRs). To reach a better physiological understanding, their study is deepening and is now focusing on structural assessments (ligand binding, dimerisation) and also on multiple signal pathway assa…
The EXPRESS-Pick small molecule screening compound stock is a collection of 460,000 druglike, small molecule compounds, available for custom selection.
Structurally diverse small molecule libraries with broad 3D pharmacophore coverage for hit identification ChemBridge offers two, complementary DIVERSet™ Libraries, each composed of 50,000 leadlike and druglike compounds. Both DIVERSet Libraries (the DIVERSet-EXP and the DIVERSet-CL) are designed to provide the greatest coverage of pharmacophore space within 50,000 compounds while maintaining chemical structure diversity. Th…
CNS-directed selection from ChemBridge's EXPRESS-Pick Collection screening compound stock.
Kinase-directed selection from ChemBridge's EXPRESS-Pick Collection screening compound stock.
Roche NimbleGen provides a unique combination of high-density arrays, long-oligo probes, and flexible design capability that together provide superior results for advanced gene expression analysis. NimbleGen microarrays enable accurate, sensitive, and specific interrogation of genome-wide expression for any sequenced and annotated genome. Researchers also can tile through a genome at any desired spacing to discover genome-wide…
BlueScreen HC uses a single cell strain, which permits 8 compounds to be tested across 8 dilutions (2-fold serial), together with untreated and positive controls, in one 96-well microplate. After arraying test compounds and dilutions, growing cells are added to each well. For studies without S9 metabolic activation data are collected after incubation (48h) using a multimode microplate reader. For studies incorporating S9 metab…
The Strep-tag® / Strep-Tactin® purification system allows the isolation of above 95% pure and functional proteins after one chromatographical step. The Strep-tag system is based on the highly selective and easily controllable interaction between the Strep-tag II peptide and the specially engineered streptavidin called Strep-Tactin. The binding affinity of Strep-tag II to Strep-Tactin is nearly 100 times higher than to Stre…
FasL-Strep, a stable homotrimer, efficiently induces the CD95 pathway of apoptosis and is highly suited for evaluation of CD95 (Fas) receptor-ligand interaction. Human or murine FasL-Strep (CD95L-T4) is an engineered human or murine Fas (CD95) ligand. C-terminal fusion of the T4-FOLDON to the extracellular FasL (CD95L) receptor-binding domain (E142-L281) results in bioactive, conformationally stabilized, well defined trimers…
The recently launched Strep-Tactin® Superflow® high capacity resin offers improved binding capacity but identical high protein purity compared to standard Strep-Tactin® Superflow®. Thus, it is the perfect solution for Strep-tag® protein purification. Both Strep-Tactin® Superflow® resins • combine outstanding flow characteristics with superior mechanical stability • are suitable for increased flow rates and useful for purificat…
Agilent’s contract Lead Discovery Service utilizes label-free RapidFire technology for direct quantitation of a wide range of native analytes across diverse therapeutic areas. Supports SAR programs via retesting of hits. Uses your existing assays or RapidFire custom-developed assays. Quick data turnaround for faster drug discovery decisions.Screened as singletons or compressed format The ideal candidate assays are often the sa…
The universal grinder for every application
The most precise way of sample division
Feature uniform skirt heights for greater robotic gripping surface Solvent resistant polypropylene provides compatibility with many common organic solvents (e.g., DMSO, ethanol, methanol) DNase- and RNase-free Total volume is 360 µL; recommended working well volume is 75 to 200 µL Without lids; lids, sealing mats and tapes supplied separately
1 x 96-well plate, includes coupled magnetic beads and detection antibodies, buffers, lysis factor QG, diluent, streptavidin-PE, 96-well flat bottom plate, and plate seals for the detection of 9 MAPK pathway markers
Specify the genes you want to capture, and ship your genomic DNA samples to febit. febit’s experts will capture your region of interest with our HybSelect technology and send back the captured DNA to you with suggestions for the sequencing run on your SOLiD 3 system or your Illumina GAII system. Benefits • Short turn around time • Fast probe design • Available catalog Biochips for detection of cancer genes • Excellent enrichme…
Fast service from sample to ready-to-publish data • Up-to-date miRNA arrays based on the latest miRBase version (http://www.mirbase.org/) • Flexible and fast array design for customized biochips • From sample submission to data results report in 2–3 weeks Comprehensive analysis report of your data for publication-ready results • Sample amount: only 130 ng total RNA needed
The introduction of NGS technologies into the market has changed the way we think about scientific approaches in basic, translational and clinical research. The development of NGS applications is a rapidly evolving field – making for exciting times in genomic studies. The ability to produce large numbers of readouts at low cost makes NGS platforms useful for many applications. Next-generation sequencing applications include:•…
Sensitive DNA damage assessment Very low compound requirement Rapid turnaround, ideal for screening Reliable testing by genetic toxicology experts Assay Principles The Comet assay, also called single cell gel electrophoresis, is a technique used for the sensitive detection of DNA damage in individual cells following exposure to a test compound. Electrophoresis is performed on exposed cells that have been embedded i…
CYTOOplates are optical grade, glass-bottom microplates in 96 or 384-well format with black-side upper structures for fluorescence applications offering reduced background and minimum scattered light. Each well holds an array of over 4,000 (96-well) or 1,000 (384-well) identical micropatterns. CYTOOplates are compatible with your High Content Screening equipment.
The CYTOOchamber™ is a 35mm footprint device specially designed and manufactured for the 2x2cm² square CYTOOchip™ format which enables you to do high resolution timelapse microscopy. The CYTOOchamber uses a patented magnetic system for easy assembly. The CYTOOchamber has the same footprint as standard 35mm culture dishes and therefore will fit into all 35mm microscope stage adaptors. Components: • 1 bottom plate • 1 upper mai…
SCOPE OF APPLICATION ASEPTIC FILLING • Pharmaceutical • Diagnostic • Biopharmaceutical • Disposable filling • Aseptic liquid filling • Peristaltic liquid filling • No cleaning validation • Easy product change-over • Ideal for small batch production • No cross contamination • High accuracy filling VERY COMPACT Machine dimensions are 1.13 x 2.05 m, i.e. FMB210 takes up very little space in a cleanroom. SHORT CHANGE OVER TIME Ide…
