Drug discovery > Target Discovery Products & Reviews

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Products, services, reviews and techniques used in the identification and validation of the disease-causing target genes and proteins.

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AD6020 Aspirate / Dispense Platform

BioDot Inc.

The AD6020 combines BioDot’s precision low volume dispensing technologies and a large customizable nest to create a high throughput, multi-channel automated liquid handling workstation. Nests for MTPs and slides are available or the system can be customized for unique spotting surfaces and/or labware. Manufacturing throughput can be optimized through single/dual shuttle nest designs.

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CM5000 Guillotine Cutter

BioDot Inc.

Features:Cost Efficient - Friction-fed mini rollers eliminate unnecessary waste of the master stripUser FriendlySimple handheld operationSafety interlock deviceEasy blade cleaningFlexibleAdjustable material guidesVarious blade speedsProduct OptionsLeading Edge SensorTarget Sensor (requires Leading Edge Sensor)Anti-StaticCustom OptionsReel FeedBottle Collection

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XYZ3210 Dispense Platform

BioDot Inc.

Features:Precision Dispensing - Quantitative dispense volumesFlexibleOptional configurations to have AirJet HR, BioJet HR, FrontLine HR, or PolyDrop dispensersMenu driven operating softwareMagnetic NestFootprint - Small design that can accommodate R&D and manufacturing needsMulti-Mode DispensingLine dispensingDot dispensingSuitable for Lateral Flow, Immunoblot, and Flow Through applications

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XYZ3060 Dispense Platform

BioDot Inc.

The XYZ3060 dispensing system is a versatile tool for developing and manufacturing diagnostic tests. The system is capable of simultaneous printing of lines with non-contact or contact dispensers as well printing dots.

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LM9000 Continuous Laminator

BioDot Inc.

The Automated Laminating system is a modular design to accommodate various numbers and types of materials. Each material is fed from adjustable spindles through guides and under a pressure roller to assure complete adhesion to the plastic support backing. The system provides the ability to individually remove kiss cut adhesive liners for individual laminate materials. For fragile materials like nitrocellulose, alignment is con…

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miRCURY LNA™ microRNA Knockdown Probes

Exiqon

Exiqon miRCURY LNA™ microRNA Knockdown Probes High-affinity miRCURY LNA microRNA Knockdown Probesfor specific in vitro knockdown of microRNAs. Featuring minimal cytotoxicity and high biological stability. Key features of miRCURY LNA™ microRNA Knockdown Probes include:• Effective and sequence-specific antisense inhibition of microRNAs • Probes available for all known microRNAs • Superior biological stability • Minimal cytotoxi…

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CELLnTEC Epidermal 3D Cell Systems

Merck

New Release 2009! 3D Prime Culture Medium. Improving still further our originial medium for 3D culture of epidermal keratinocytes, CELLnTEC has now released a new formulation, known as 3D Prime.Developed using our established signalling-based approach, this completely defined medium enables more rapid establishment of a fully stratified epidermis. Using this medium, models can now be ready for experimentation in just 14-18 day…

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Corning® 1000 mL Bottle Top Vacuum Filter, 0.22 µm Pore 54.5cm² CA Membrane, Fits 45 mm Diameter Necks, Sterile, 12/Case

Corning Life Sciences

Fits plastic or glass media bottles with 45mm neck sizes. Cellulose acetate (CA) membranes provide fast flow rates and low protein binding and are good for filtering cell culture media. Angled hose connector simplifies vacuum line attachment. Individually packaged, sterile and certified nonpyrogenic. Each system has the membrane material and pore size printed on the unit and is color-coded by membrane type for easy produ…

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PCT Mammary Epithelium Medium (Human)

Merck

CnT-27 is a progenitor cell targeted (PCT) liquid culture medium kit including both basal medium and separate supplements, developed for improved isolation and growth of mammary epithelium. CnT-27 is fully defined, serum and BPE-free formulation. It does not contain antibiotics / antimycotics. The basal medium contains amino acids, minerals, vitamins and organic compounds, but is protein free.

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Mirus Bio TransIT*-Prostate Transfection Kits

Fisher Scientific

Optimized to achieve over 50% transfection efficiency without sacrificing cellular health, each kit includes an optimized protocol, Prostate Reagent and Prostate Boost Reagent in sufficient quantities to conduct up to 500 transfections in 35mm wells.Features include:• Reduces levels of cell damage when compared to liposmal-based transfection reagents • Transfection can be conducted in serum-containing media to save time and el…

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Human Activin A Biotinylated Fluorokine™ Kit

Bio-Techne

R&D Fluorokine Receptor Detection Kits - Biotinylated ligands for estimating receptor densities R&D Systems now offers a Human Activin A Biotinylated Fluorokine Kit (Catalog # NFACTA). This flow cytometry kit is designed for the detection of Activin A receptor-expressing cells by flow cytometry. Activin A is a disulfide-linked homodimer belonging to the TGF-beta superfamily that signals through Type I/Type II receptor comple…

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Mouse Obesity Antibody Array

Bio-Techne

R&D Mouse Obesity Antibody Array - Proteome Profiler Array - For the parallel determination of the relative levels of selected mouse Adipokines. R&D Mouse Obesity Array (Catalog # ARY013) is a rapid, sensitive, and economical tool used to simultaneously detect the relative levels of 38 different obesity-related molecules in a single sample. No specialized equipment is necessary.  R&D Mouse Obesity Antibody Array for the meas…

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ProteaseMAX™ Surfactant, Trypsin Enhancer

Promega Corp.

ProteaseMax™ Surfactant is a high-quality reagent for use in protein and peptide sample preparation.   ProteaseMax™ Surfactant solubilizes proteins and ensures fast and improved protein digestion with trypsin or chymotrypsin. It is designed to degrade over the course of a digestion reaction, yielding products that are compatible with downstream methods such as mass spectrometry (MS) and liquid chromatography (LC). For…

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ESGRO Complete PLUS Clonal Grade Medium

Merck

ESGRO Complete PLUS Clonal Grade Medium is a defined serum-free medium provided with a selective GSK3β inhibitor to enhance viability of mouse embryonic stem (ES) cells and increased maintenance of pluripotency in the absence of serum and feeder cells. This medium is intended for mouse ES cell expansion and growth at clonal density in serum-free conditions. The mouse ES cells should maintain germ line competency. Suitable fo…

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Thermo Scientific Neurite Outgrowth Reagent Kit

The Neurite Outgrowth HCS Reagent Kit product provides a more effective solution for quantifying neurite outgrowth by combining high-content screening (HCS)-quality fluorescence reagents with a validated, automation-compatible protocol. Neurite Outgrowth Reagent Kit Features: Neuronal-specific fluorescent reagent identifies neuronal cell bodies and neurites in a heterogeneous cell population without isolation steps Val…

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LifeXtend™ HRP Conjugate Stabilizer/Diluent

Innova Biosciences Ltd.

LifeXtend™ conjugate stabilizer/diluent is a proprietary multi-component reagent system that stabilizes antibody-HRP conjugates both at 4°C and at ambient temperature. By using LifeXtend™ HRP stabilizer/diluent in antibody conjugation the HRP conjugate can be stabilized during use and stored as pre-diluted, ready-to-use reagents thus eliminating waste and improving consistency from experiment to experiment. LifeXtend™ shows…

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HTRF® SIRT (new format)

Cisbio Bioassays

SIRT1 belongs to the class III family of HDACs, which are NAD+ dependent enzymes. SIRT1 modulators have been shown to play a beneficial role in treating diseases such as cancer, diabetes, metabolic disease and inflammation, making them attractive targets for the development of new drugs. The new HTRF® SIRT1 assay, developed by Cisbio Bioassays using its patented HTRF technology, is a homogeneous method for directly measuring S…

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Thermo Scientific Whole Cell Stains

These stains are intense, highly photostable and match the output wavelengths of common fluorescence instrumentation. Effective image analysis in HCS cell-based assays and fluorescence microscopy requires fluorescent labeling of the entire cell. In these assays, the cellular primary object is used to identify and count individual cells and define the cell region in which the image analysis is applied. The primary object migh…

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Thermo Scientific Cytotoxicity 3 Multiparameter Kit

This kit enables simultaneous measurements in the same cell of six independent parameters that monitor cell health, including cell loss, nuclear size and morphological changes, mitochondrial membrane potential changes, cytochrome c release, and changes in cell permeability.

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Thermo Scientific Multiparameter Cell Death Detection Kit

The Multiparameter Cell Death Detection Kits for high-content screening (HCS) enable simultaneous quantitation of LC3B protein on autophagic vesicles, cytochrome c localization and its release from mitochrondria, cell membrane integrity and its permeability and nuclear morphology and DNA content.

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