Drug discovery > Target Discovery Products & Reviews

Aryl hydrocarbon receptor (AHR) antagonist

Calcium signaling inhibitor; Inhibits calcium/calmodulin-dependent kinase kinases (CaMKKs)

HGF pathway inhibitor; Inhibits MET

MEK/ERK pathway inhibitor; Inhibits VEGFR2, FGFR1, and PDGFRB

Tyrosine kinase inhibitor; Inhibits of KDR, PDGFR, KIT, RET, FLT-3, ABL and ALK

Cyclin/CDK pathway inhibitor; Inhibits CDK1 and CDK2

Tryosine kinase inhibitor and epigenetic modifier; Inhibits PDGF, FGF, EGF, TGFß, SIRT1, and SIRT5

Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor

JAK/STAT pathway inhibitor; Inhibits JAK2

RHO/ROCK pathway inhibitor; Inhibits ROCK

HGF pathway inhibitor; Inhibits MET

mTOR pathway inhibitor; Inhibits mTORC1 and mTORC2 complexes

Epigenetic modifier; Inhibits lysine-specific demethylase 1 (LSD1)

Epigenetic modifier; Inhibits histone deacetylase (HDAC)1 and HDAC6

NF-kB pathway inhibitor; Activates PPAR?

Retinoid pathway activator; Activates retinoic acid receptor (RAR)

WNT pathway activator; Inhibits GSK3ß

MEK/ERK pathway inhibitor; Inhibits MEK1 and MEK2

Pyrimido-indole derivative that enhances HSC self-renewal in vitro

Epigenetic modifier; Inhibits histone deacetylase (HDAC)1

Regulated upon activation, normal T cell expressed and secreted

Xeno-free, defined, feeder-free medium for maintenance of undifferentiated human ES and iPS cells

Defined, animal component-free medium for differentiation of human ES and iPS cells to multiple lineages

qPCR analysis kit for detecting the majority of karyotypic abnormalities reported in human ES and iPS cells

Enzyme-free cell dissociation reagent