Drug discovery > Target Discovery Products & Reviews

Corning® IL-3 Culture Supplement, mouse, 25 mL, is used to culture a variety of IL-3 responsive cells, e.g., mast cells, basophils, natural killer cells, and several hematopoietic precursor cells, 1/pack. These cytokines have been used to promote long-term proliferation in cell culture and to induce cell-mediated immune responses in a variety of cell types.StorageShelf life: >= 3 months from date of shipment at 2-8°C (Do not f…

Corning® Interleukin-2 (IL-2), human recombinant, 10,000 BRMP units, promotes long-term proliferation of activated T-cells. Also known as T-cell growth factor, Interleukin-2 (IL-2) plays a central role in cell-mediated immune response. 1/pack. These cytokines have been used to promote long-term proliferation in cell culture and to induce cell- mediated immune responses in a variety of cell types.FormulationFrozen in 55 mM sodi…

Corning® Epidermal Growth Factor (EGF), human recombinant, 100µg, is a low-molecular-weight mitogenic protein that stimulates proliferation of a wide variety of cell types in vitro. 1/pack. These growth factors have been used to promote long-term proliferation in cell culture and to induce cell differentiation in a variety of cell types under serum-free or reduced serum conditions.FormulationLyophilized from acetic acid, carri…

Corning® basic Fibroblast Growth Factor (bFGF), human recombinant, 10µg, is a heparin-binding mitogenic protein that enhances the proliferation of a wide variety of cell types under serum-free or serum-reduced conditions. 1/pack, formerly Cat. #40060. These growth factors have been used to promote long-term proliferation in cell culture and to induce cell differentiation in a variety of cell types under serum-free or reduced s…

Corning® T-Cell Culture Supplement with ConA (IL-2 culture supplement), rat, 100 mL, used to promote proliferation and activation of T-cells and support high-titer HIV production by leukocytes. 1/pack, formerly Cat. #40115StorageShelf life: >= 3 months from date of shipment at 2-8°C

Corning® Bovine Pituitary Extract (BPE), 15mg, is a broadly used supplement to culture a variety of epithelial and endothelial cells. BPE contains growth factors (e.g., basic FGF) and hormones. 1/packSourceBovine pituitary glandsQuality Tested for ability to promote proliferation of Fetal Bovine Heart Endothelial Cells (FBHEC) in medium containing 10% newborn calf serum Filtered (0.2 µm membrane) and tested and found negativ…

This is suggested replacement for 354141.Corning® BioCoat™ Angiogenesis System for Endothelial Cell Invasion comprises a 3.0 µm Corning FluoroBlok™ PET Membrane 24-well Permeable Support System pre-coated with Corning® Matrigel®. Packaged ready to use with Falcon® Companion Plate, 1/case Allows rapid data collection Eliminates need for manual cell scraping and counting Increases throughput and productivityShelf life: >= 3 m…

This is suggested replacement for 354143.HTS insert plates are arrays of individual cell culture inserts connected by a rigid, robotics-friendly holder. This single-unit design makes insert plates ideal for running automated, high throughput drug transport (Caco-2 cells) cell toxicity studies or cell migration and invasion studies.• Predictive in vitro model for screening pro- and anti-angiogenic compounds Optimized human f…

Highly reproducible assay system Ideal for screening anti-angiogenic agents Rapid image acquisition and data quantification

Highly reproducible assay system Ideal for screening anti-angiogenic agents Rapid image acquisition and data quantification

Corning® Poly-D-Lysine, 20mg, is used to culture a wide variety of cell types, particularly neurons, glial cells, and transfected cells.SourceSyntheticQualityShown to promote cell attachment and spreading of rat cerebellar granule cellsFound negative for bacteria, fungi, and mycoplasmaMolecular Weight500-550 kDPreparation and StorageStable for three months at 2° to 8°C (lyophilized) or three months at -20°C (solubilizedHandlin…

Corning® rLaminin-521, Human, 20μg Vial Corning rLaminin-521 (Human) is a heterotrimer composed of α5, β2, and γ1 chains expressed in a mammalian cell culture system. rLaminin-521 (Human) supports long-term self-renewal of human pluripotent stem cells (hPSC), including embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) in defined and xeno-free environments. rLaminin-521 provides additional benefits, includin…

Corning® rLaminin-521, Human, 100μg Vial Corning rLaminin-521 (Human) is a heterotrimer composed of α5, β2, and γ1 chains expressed in a mammalian cell culture system. rLaminin-521 (Human) supports long-term self-renewal of human pluripotent stem cells (hPSC), including embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) in defined and xeno-free environments. rLaminin-521 provides additional benefits, includi…

Corning® Collagen I, bovine, 30mg, is used either as a thin layer on tissue-culture surfaces to enhance cell attachment and proliferation, or as a gel to promote expression of cell-specific morphology and function. (Same as Cat. #40231)SourceBovine dermisQualityPurity > 95% by SDS-PAGEShown to promote attachment and spreading of HT-1080 human fibrosarcoma cellsTested for formation of a firm gel by exposure to ammonia vapors fr…

Corning® Laminin, mouse, 1mg, is used as a thin coating on tissue-culture surfaces or as a soluble additive to culture medium. Laminin is a major component of basement membranes. It has numerous biological activities including promotion of cell adhesion, migration, chemotaxis, growth, and differentiation, including neurite outgrowth.QualityPurity >90% by SDS-PAGE (contains entactin)Tested for ability to initiate neurite outgro…

Corning® Collagen IV, mouse, 1mg, is used as a thin coating on tissue-culture surfaces to promote cell attachment and proliferation and to study the collagen's effects on cell behavior.SourceSource material tested for HBsAG, for anti-HIV-1 and anti-HIV-2, and anti-HCV virus-1 and virus-2.QualityElectrophoretically homogeneous (SDS-PAGE)Tested and found negative for bacteria, fungi, and mycoplasmaPreparation and StorageStable f…

Corning® Collagen I, rat tail, 100mg, is used either as a thin layer on tissue-culture surfaces to enhance cell attachment and proliferation, or as a gel to promote expression of cell-specific morphology and function.SourceRat Tail TendonQualityPurity = 90% by SDS-PAGETested for: ability to promote attachment and spreading of HT-1080 human fibrosarcoma cellsForms firm gel up to a dilution of 1:10; further dilution will decreas…

Corning® Ultrapure Laminin, mouse, 1mg, is entactic free and is used as a thin coating on tissue-culture surfaces or as a soluble additive to culture medium. Laminin is a major component of basement membranes. It has numerous biological activities including promotion of cell adhesion, migration, chemotaxis, growth, and differentiation, including neurite outgrowth.QualityPurity > 95% by SDS-PAGETested for ability to initiate ne…

Corning® Collagen I, human, 0.25mg, is used either as a thin layer on tissue-culture surfaces to enhance cell attachment and proliferation, or as a gel to promote expression of cell-specific morphology and function. (Same as Cat. #40243)SourceHuman PlacentaQualityElectrophoretically homogeneous (SDS-PAGE)Shown to promote attachment and spreading of HT-1080 human fibrosarcoma cellsTested and found negative for bacteria, fungi,…

Corning® Collagen IV, human, 0.25mg, is used as a thin coating on tissue-culture surfaces to promote cell attachment and proliferation and to study the collagen's effects on cell behavior.SourceHuman placenta. NOTE: Source material tested for HBsAG, for anti-HIV-1 and anti-HIV-2, and anti-HCV virus-1 and virus-2.QualityElectrophoretically homogeneous (SDS-PAGE)Tested and found negative for bacteria, fungi, and mycoplasmaPrepar…

Corning® Cell Recovery Solution, 100 mL, enables the recovery of cells cultured on Corning® Matrigel® Basement Membrane Matrix for subsequent biochemical analyses.QualityTested for ability to depolymerize a 1mm thick layer of gelled Matrigel Matrix after one hour at 2° to 8°CFiltered (0.2 µm membrane) and tested for bacteria, fungi, and mycoplasmaPreparation and StorageStable for at least three months at 2° to 8°C.HandlingCorn…

Laminin is a major component of basement membranes. It has numerous biological activities including promotion of cell adhesion, migration, chemotaxis, growth, and differentiation, including neurite outgrowth.Molecular Weight900 kD (unreduced)SourceEngelbreth-Holm-Swarm (EHS) mouse tumorQualityPurity >/ 90% by SDS-PAGETested for ability to initiate neurite outgrowth of NG-108 Mouse neuroblastoma cellsFound negative for the pres…

Corning® Collagen I, human, 10mg, is effective as a gel or thin coating at a recommended concentration of 0.2-2µg/cm2 of growth surface depending on cell type (guidelines for coating included with product).FormulationFrozen in 2mM HClSourceHuman placenta. Source material tested for hepatitis B antigen and HIV-1 antibody.QualityElectrophoretically homogeneous (SDS-PAGE)Shown to promote attachment and spreading of HT-1080 human…

Corning® ITS Premix Universal Culture Supplement, 5 mL, contains insulin, human transferrin, and selenous acid, the three most universally essential components of defined culture media. The concentrated supplement stimulates cell proliferation of a variety of cells under serum-reduced conditions. 5 mL (5L equivalent), 1/packThe ITS Premix (354350 and 354231) contains the following when used at the recommended dilution: Insulin…

Corning® ITS + Premix Universal Culture Supplement, 20 mL, contains insulin, human transferrin, and selenous acid, the three most universally essential components of defined culture media. The concentrated supplement stimulates cell proliferation of a variety of cells under serum-reduced conditions. 20 mL (2L equivalent), 1/packFormulationCorning ITS+ Premix: As an aqueous solution containing human recombinant insulin, human t…