Drug discovery > Target Discovery Products & Reviews

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Products, services, reviews and techniques used in the identification and validation of the disease-causing target genes and proteins.

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SIRTainty™ Class III HDAC Assay

Merck

The SIRTainty™ Class III HDAC Assay utilizes a novel patent pending technology for the sensitive detection of all known sirtuin family members. This easy to perform assay employs nicotinamidase to measure nicotinamide generated upon cleavage of NAD+ during sirtuin mediated deacetylation of a substrate providing a direct assessment of the activity of class III HDAC enzymes. Unlike conventional assays that are dependent upon a s…

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MILLIPLEX MAP Human Stem Cell Pluripotency Magnetic Bead Panel 1 - Stem Cell Multiplex Assay

Merck

Product Overview: The MILLIPLEX® Human Stem Cell Pluripotency Magnetic Bead Panel 1 (Cat. No. 48-617MAG) is a premixed panel to be used for the simultaneous quantification of the following 4 analytes in cell lysates: c-Myc, Nanog, Oct 3/4, and Sox2. The detection assay is a rapid, convenient alternative to Western Blotting and immunoprecipitation procedures. Each kit has sufficient reagents for one 96-well plate assay. Backgro…

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MILLIPLEX MAP Human Stem Cell Pluripotency Magnetic Bead Panel 2 - Stem Cell Multiplex Assay

Merck

Product Overview: The MILLIPLEX® Human Stem Cell Pluripotency Magnetic Bead Kit 2 (Cat. No. 48-620MAG) is a premixed kit to be used for the simultaneous quantification of the following 7 analytes in cell lysates: E-Cadherin, EpCam, KLF4, LIN-28, and the glycostructures TRA-1-60, TRA-1-81 and SSEA1. The detection assay is a rapid, convenient alternative to Western Blotting and immunoprecipitation procedures. Each kit has suffic…

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CX & CXR Series

Taylor-Wharton

Cryo Express (CX) “dry shippers” are designed to safely transport a variety of materials at cryogenic temperatures. The unique absorbent material prevents a liquid spill if the unit is tipped over. Storage temperature inside the shipping cavity remains at approximately -190˚C until the liquid nitrogen evaporates from the absorbent material. CX & CXR Series Features: Advanced Concept Absorbent enables faster charging Co…

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XT Series

Taylor-Wharton

The Extended Time Series (XT) Series of cryogenic refrigerators are designed for long-term storage of a variety of materials at cryogenic temperatures. This series also offers low profile models (XTL), with 5” canisters. XT Series Features: New Rugged Construction – ribbed high strength aluminum body, magniformed necktube design, and more durable paint Versatile storage system – convenient canister numbered index location…

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Rocket 4D Synergy Large Volume Evaporator

Genevac

Rocket 4D Synergy is designed primarily to evaporate large sample volumes, with autofeed if required, allowing automatic evaporation of volumes up to 100 litres. Rocket 4D Synergy provides fast, safe evaporation for solvents with a boiling point of up to 165°C (DMF) and can easily dry aqueous samples. The system feeds the solution for evaporation to the evaporation vessel, controls temperature and pressure, prevents bumping…

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Magna ChIP™ HiSens Chromatin Immunoprecipitation Kit

Merck

The Magna ChIP HiSens kit provides a complete set of validated, quality controlled reagents, and a detailed protocol to enable ChIP from a wide range of input amounts of chromatin obtained from either cells or tissues. Our specialized blend of protein A/G blend of magnetic beads is specifically produced for chromatin immunoprecipiptation and enables the use of a broader range of antibodies than protein A or G alone eliminating…

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F2H Assay Kit

Chromotek GmbH

F2H®-Kit Basic for effortless imaging of interactions between GFP- and RFP-tagged proteins of interest and domains thereof in live mammalian cells. The Fluorescent Two- Hybrid (F2H®) Technology is a fast and simple way to study protein-protein interactions (PPIs) by conventional fluorescence microscopy. Its direct optical readout is optimal for high-content analysis (HCA) and screening for PPI inhibitors.F2H® Principle: F…

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MethylCap kit

Diagenode

The MethylCap assay is based on the affinity purification of methylated DNA using a MBD (Methylbinding domain) protein . This procedure has first been optimized on the SX-8G IP-Star Automated System ([page product SX-8G IP-Star]. Afterwards, this method has been adapted to a manual protocol, which has been inspired by the same reproducibility standards provided by the automated MethylCap assay. Allows for fractionati…

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PureEpi™ Chromatin Preparation and Optimization Kit

Merck

The PureEpi Chromatin Preparation and Optimization kit provides a complete set of reagents allowing the preparation of multiple chromatin samples from starting materials such as cultured cells or tissues. A detailed protocol is provided that includes examples of the many variables involved in making chromatin on multiple instruments and how they may affect ChIP results. Features & Benefits • Complete set of materials for up to…

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GeSiM Nano-Plotter™ Non-Contact Nanolitre Dispenser

Analytik Ltd

The Nano-Plotter™ series are ideal for generating high-quality spots by non-contact dispensing of sub-nanolitre volumes. The highly versatile “drop on demand” piezoelectric technology allows the placement of drops onto a variety of substrates with outstanding precision, and also the mixing of samples into pre-filled cavities to run nano-assays. These compact instruments are your ideal solution for the development and producti…

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DNAQual Kit

Eurobio Laboratories

DNAQual kit is used for the quantitative assessment of DNA degradation by quantifying the number of copies of a target gene compared to a calibrator gene (included in the kit) in any human DNA sample by qPCR in duplex in 90 minutes. The two genes (target and calibrator are measured with two specific probes carrying each a different fluorophore: Texas Red for the calibrator and VIC for the target gene. The software on the qPCR…

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Thermo-ShakeX ELM

Xiril AG

The Thermo-ShakeX ELM – working reliable, smooth and quet on a Xiril liquid handling robotic workstation – is the answer to all your automated plate shaking&heating needs. Thermo-ShakeX ELM Features: Edge locking mechanism (ELM) allows safe positioning and optimal gripping of different plate types Vibration- and splatter-free mixing in orbital motion, up to 3000 rpm All SBS format plate types easily shakeable* (*stan…

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Sonata - Cell Culture System

TAP Biosystems

Sonata System - Automated cell culture of mammalian or insect cells in shake flasks. Sonata is designed to automate the cell culture of mammalian or insect cells growing in suspension in shake flasks. Sonata System Automates: Maintenance of cell stocks Cell line characterisation & selection Culture optimisation – fed batch Stability testing Protein expression Sonata System Benefits: Automation of existing pr…

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ambr 250 - Bioreactor System

TAP Biosystems

ambr 250™ is a new bioreactor system for parallel fermentation using single-use bioreactors controlled by an automated workstation. The new system, developed with two major industrial partners, builds on TAP’s successful microbioreactor technology, adding increased fermentation volumes, as well as individual bioreactor temperature and impeller control. ambr 250 provides an efficient, high throughput scale-down model for proces…

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Subboiling BSB-939-IR

Berghof Products + Instruments GmbH

High-Purity Acids, Always fresh to hand thanks to Subboiling. As rule, chemical prices increase exponentially as the chemical’s purity increases. Therefore, even where annual consumption is apparently minimal, high-purity acids can quickly become a significant cost factor for trace analysis laboratories. These costs can be avoided by the employment of a subboiling apparatus to produce high-purity acids from more economical…

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cOmplete His-Tag Purification Column

cOmplete His-Tag Purification Column - Prepacked columns with EDTA-compatible resin for the purification of poly-histidine-tagged proteins. cOmplete His-Tag Purification Columns are available in 2 different sizes and prepacked with cOmplete His-Tag Purification Resin. cOmplete His-Tag Purification Resin is an innovative high-capacity IMAC matrix (Immobilized Metal Affinity Chromatography) for convenient single-step purificati…

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Prima BT Bench top Mass Spectrometer

Thermo Fisher Scientific

Prima BT Bench top Mass Spectrometer - Highly reliable, precise, and flexible gas analyzer specifically designed for process development laboratories. The Thermo Scientific Prima BT Bench top Mass Spectrometer is an industrial laboratory gas analyzer based on scanning magnetic-sector mass spectrometry. Designed for continuous operation in a process environment, the Prima BT mass spectrometer is simple to operate and easy to m…

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Corning® 1700cm² Expanded Surface Polystyrene Roller Bottle with Easy Grip Cap, 20 per Bag, 20 per Case

Corning Life Sciences

Ribbed design provides twice the surface area with the same exterior dimensions. Bottles are manufactured from virgin polystyrene, caps from high density polyethylene Both resins meet the USP Class VI requirements for plastic containers and closures Treated for optimal cell attachment One piece seamless construction with printed graduations Printed lot numbers to aid in product traceability Sterilized by gamma radiatio…

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NEBNext® ChIP-Seq Library Prep Master Mix Set for Illumina®

New England Biolabs Inc.

The NEBNext® ChIP-Seq Library Prep Master Mix Set for Illumina® contains enzymes and buffers in convenient master mix formulations that are ideally suited for sample preparation for next-generation sequencing. NEBNext® reagents are a series of highly pure reagents that facilitate sample preparation of DNA or RNA for downstream applications such as next generation sequencing and expression library construction. The reagents in…

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