Drug discovery > Pre-Clinical Development Products & Reviews

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Products, services, reviews and techniques used in lead molecule delivery, formulation and toxicology, using assays and animal models.

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Prospect T2 High-frequency Ultrasound System For Preclinical Imaging

Scintica

The Prospect T2 is an innovative high-frequency ultrasound system designed specifically for in vivo preclinical imaging in small animals such as mice and rats. This compact and cost-effective tablet-based system provides high-resolution images (up to 30 µm) and advanced capabilities to monitor changes in hemodynamics and observe anatomical structures in real-time.

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OpenSPR®

Nicoya

OpenSPR® provides real-time, label-free SPR data at a fraction of the cost of existing solutions. Highly sensitive while being simple to maintain and operate, OpenSPR has been used by hundreds of researchers to generate publication-quality data.

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Myelotracker® - Labeling Kit

Bertin Technologies

Myelotracker® is a cutting-edge fluorescent probe that enables precise detection of neutrophils—essential immune cells—in both blood and tissue samples. It offers researchers a dependable tool for exploring inflammation, infections, and immune system activity.

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MultiVial

Labman Automation

Weigh, image and mark glass and plastic vials, all in one compact benchtop unit - this is MultiVial. Modular & configurable to your exact requirements, this versatile system offers fast and efficient processing of vials for your lab.

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MassivEV™ EV Purification Column PS

FujiFilm Wako Chemicals Europe GmbH

Fujifilm Wako has developed the MassivEV™ EV Purification Column PS, which utilizes our proprietary EV isolation and purification technology known as the PS affinity method1). Used in conjunction with the specialized MassivEV™ Purification Buffer Set (Product Number: 295-96601), this system enables convenient isolation and purification of EVs, including exosomes, from liter-scale cell culture supernatants.

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GeneDirectory

Syngene

Band pattern analysis database GeneDirectory is a fast data storage and retrieval system designed for large-scale genomic fingerprinting studies, cluster analysis, VNTR analysis, genotyping and RFLP. Used in conjunction with the GeneTools gel analysis package, this combination is the most powerful and user-friendly comparison tool available today, saving you hours of repetitive work by automatically comparing thousands of…

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GeneTools

Syngene

Syngene GeneTools - Advanced 1D gel analysis Syngene GeneTools is an advanced 1D gel and 2D spot blot analysis software for use with any gel documentation system.  The Syngene GeneTools highly automated software can rapidly analyse a gel from loading an image to output of results in a matter of seconds.  With an extensive and flexible array of options you can handle a range of media including gels, plates, films and blots,…

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StarDrop 5 - Drug Discovery Software

Optibrium

StarDrop is a suite of software that helps you to deliver optimally balanced, effective drugs - fast StarDrop works by evaluating complex data, which is often uncertain because of experimental variability or predictive error. In scoring this data, it brings confidence and intuitive simplicity to decision-making: guiding and validating the direction you take and which compounds you prioritise. Its instantly interactive tools t…

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Apo-Direct TUNEL Assay Kit

Merck

The CHEMICON APO-DIRECT™ Kit is a single-step staining method for labeling DNA breaks to detect apoptotic cells by flow cytometry (Li et al. 1995). The kit contains all the reagents required for measuring apoptosis in cells including positive and negative control cells; washing, reaction, and rinsing buffers; and propidium iodide/RNase A solution for counter staining the total DNA.

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MitoLight® Mitochondrial Apoptosis Detection Kit

Merck

The MitoLight™ Apoptosis Detection Kit utilizes a lipophilic cation, termed as MitoLight™, as a mitochondrial activity marker. MitoLight™ is a mitochondrial dye that stains mitochondria in living cells in a membrane potential-dependent fashion. The monomer is in equilibrium with so-called J-aggregates, which are favored at higher dye concentration or higher mitochondrial membrane potential. MitoLight™ partitions differently i…

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Cell Transformation Detection Assay

Merck

CHEMICON®'s Cell Transformation Detection Assay is an anchorage-independent growth assay in soft agar, which is considered the most stringent assay for detecting malignant transformation of cells. For this assay, cells (pre-treated with carcinogens or carcinogen inhibitors) are cultured with appropriate controls in soft agar medium for 21-28 days. Following this incubation period, formed colonies can either be analyzed morphol…

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Mast Cell Degranulation Assay Kit

Merck

Chemicon's Mast Cell Degranulation Assay Kit provides a simple and convenient means for assaying tryptase activity. The assay is based on spectophotometric detection of the chromophore p-nitroaniline (pNA) after cleavage from the labeled substrate tosyl-gly-pro-lys-pNA. The free pNA can then be quantified using a spectrophotometer or a microtiter plate reader at 405 nm. A pNA Standard is provided as a comparison control.

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Neurite Outgrowth Assay Kit (3 μm)

Merck

CHEMICON's NS220 Neurite Outgrowth Assay Kit (3 µm) utilizes microporous tissue culture insert technology from EMD Millipore and is based on the use of Millicell cell culture inserts (chambers) containing a permeable membrane with 3-μm pores at the base. The Millicell inserts utilized in this kit are appropriate for cells projecting neurites of up to 3 µm diameter, e.g. N1E-115 cells [Abe et al., 2003], Dorsal Root Ganglia and…

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Neurite Outgrowth Assay Kit (1 μm)

Merck

CHEMICON's NS225 Neurite Outgrowth Assay Kit (1 μm) utilizes microporous tissue culture insert technology from EMD Millipore and is based on the use of Millicell cell culture inserts (chambers) containing a permeable membrane with 1 μm pores at the base. With this system, it is possible to screen numerous biological and pharmacological agents simultaneously, directly evaluate adhesion and guidance receptor functions responsibl…

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ApopTag® Equilibration Buffer

Merck

ApopTag® Equilibration Buffer is intended for use in labeling the 3'-OH ends of fragmented DNA during apoptotic cell detection. Qualified for use with Apoptag® In Situ Apoptosis Detection Kits

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