Drug discovery > Lead Discovery Products & Reviews

This chemistry promotes high retention of a wide range of analytes, reducing method development time and facilitating a generic approach to sample preparation.

Functional groups, such as octyl (C8) and octadecyl (C18), can be bonded to the silica surface to provide non polar interactions.  Each of these sorbents exhibits unique properties of retention and selectivity for a particular analyte.  The choice of which sorbent is best for a particular method will be influenced by the percent recovery of analyte from the sample matrix and the cleanliness of the resulting chromatography.

SDB-XC is a poly(styrenedivinylbenzene) copolymer used as a reversed phase sorbent for solid phase extraction.  SDB-XC is not bonded to silica but is a 100% copolymeric particle that is spherical, porous and cross-linked.  It does not exhibit the secondary cationic (silanol) interactions and pH limitations common to bonded silica sorbents, so it offers more predictable and reproducible reversed phase interaction.

The Empore™ High Performance Extraction Disk Plate differs in design from plates offered by other manufacturers and requires a specific vacuum manifold.  Manifolds supplied by different plate manufacturers are specific to the design of their plates and cannot generally be used with plates from other manufacturers.  In some cases, the use of spacers to raise/lower the height of a collection device inside the manifold may overco…

Replacement gaskets are available with the vacuum manifold assembly.  The gasket can become worn over time and the seal between the plate and the manifold will be affected.  This may result in poor vacuum pressure and negatively effect flow rates.  The gasket should be checked regularly and replaced when it becomes worn.

EmporeTM Tape Pads are intended for sealing unused portions of a 96-well solid phase extraction plate during vacuum processing to enable vacuum to be uniformly applied to each well being used.  Use a clean sheet each time for maximum sealing ability.  Note: these tape sheets are not intended for sealing collection plates prior to sample injection because the adhesive may clog the injection needle.

Empore Filter Aid 400 has been shown to improve flow rates and recoveries for separation and filtration of water samples containing suspended solids.  When placed on top of the Empore™ Extraction Disk at a depth of about 1 cm, Empore™ Filter Aid 400 acts as depth filter to inhibit the migration of suspended solids to the surface of the disk.  This reduces extraction time and improves rates and recovery of analytes.

The PX Scanner is the revolutionary new product from Oxford Diffraction which has been designed specifically for the identification and analysis of protein crystals in situ within multi-well crystallisation plates. The PX Scanner is unique, having both an optical and an X-ray imager in one system. The optical imaging component allows the user to visually locate and select objects for X-ray analysis. Accepting a wide range of c…

Spark has introduced the second edition of HySphere™ C8 End-Capped cartridges. We have selected a new perfect Spherical sorbent material with a narrow particle size distribution. This will create less back pressure during operation and allows you to run higher flow rates compared to our current HySphere™ C8 (EC). The new cartridge has the same excellent characteristics such as high extraction capacity and selectivity

Fits plastic or glass media bottles with 33mm neck sizes. Cellulose acetate (CA) membranes provide fast flow rates and low protein binding and are good for filtering cell culture media. Angled hose connector simplifies vacuum line attachment. Individually packaged, sterile and certified nonpyrogenic. Each system has the membrane material and pore size printed on the unit and is color-coded by membrane type for easy produ…

Feature uniform skirt heights for greater robotic gripping surface Solvent resistant polypropylene provides compatibility with many common organic solvents (e.g., DMSO, ethanol, methanol) Certified DNase- and RNase-free Total volume is 500 µL

Source: UCSC Build: HG18, NCBI 36 Probe Length: 60mer Median Probe Spacing: 1169bp Platform: HD2 Probes per Array: 2,100,000 Feature Size: 13μm x 13μm Array Dimensions: 62mm x 14mm Overall Slide Dimensions: 1" x 3" (25 x 75mm) Recommended Storage: Store arrays desiccated at room temperature.

Kit includes OpenArray® Endpoint Analysis Software CD and user’s manual. Compatible with the NT Imager or NT Cycler.

Customer-owned TaqMan® assays reformatted on OpenArray® plates. Plates must be ordered in multiples of 10. Minimum order is 10 plates. Kit includes: Cases, Immersion Fluid, Case Sealing Glue and Plate-File CD.

Real-Time qPCR assays for kinases and related genes reformatted onto an OpenArray plate. Kit includes: OpenArray plate, Real-Time qPCR Case, Immersion Fluid, Frame Adhesive and Plate-File CD.

OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels are currently avaliable with human or mouse genes. New panels are continually under development. Check back for updates. Real-Time qPCR assays for ADME and related genes reformatted onto an OpenArray plate. Kit includes: OpenArray plate, Real…

OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels are currently avaliable with human or mouse genes. New panels are continually under development. Check back for updates. Real-Time qPCR assays for Apoptosis and related genes reformatted onto an OpenArray plate. Kit includes: OpenArray plate,…

OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels are currently avaliable with human or mouse genes. New panels are continually under development. Check back for updates. Real-Time qPCR assays for Cancer and related genes reformatted onto an OpenArray plate. Kit includes: OpenArray plate, Re…

OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels are currently avaliable with human or mouse genes. New panels are continually under development. Check back for updates. Real-Time qPCR assays for Cardiovascular Disease and related genes reformatted onto an OpenArray plate. Kit includes: Ope…

OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels are currently avaliable with human or mouse genes. New panels are continually under development. Check back for updates. Real-Time qPCR assays for Inflammation and related genes reformatted onto an OpenArray plate. Kit includes: OpenArray pla…

Real-Time qPCR assays for Signal Transduction and related genes reformatted onto an OpenArray plate. Kit includes: OpenArray plate, Real-Time qPCR Case, Immersion Fluid, Frame Adhesive and Plate-File CD.

An acetyl-biotinylated substrate recognized by a Eu3+ anti-acetyl MAb and SA-XL665, which is used in activator screening or to test an High Throughput SIRT1 inhibitor.  The level of enzymatic activity is inversely proportional to the amount of signal produced in the system. For more information please visit Cisbio Bioassays website.

VICI introduces the GC detector where the PDD (pulsed discharge detector) utilizes a stable, low-powered, pulsed DC discharge in helium as the ionization source. The D-2 is a dual mode, universal detector system which can be retrofitted to your older GC. The D-2-I is a helium photoionization detector, optimized for trace level work with packed columns. The stand-alone systems include detector, controller, electrometer, helium…

Pulsed discharge detector Model D-3 is designed for plug-and-play installation on Agilent GC's, with models available for the 6890 and 7890. The D-3 is optimized for trace level work in the helium photoionization mode, and utilizes the electronics and power supply of the host GC. Model D-5 is optimized for electron capture detection. Available for 110 VAC and 230 VAC.

Model D-5 is a pulse discharge GC detector designed for plug-and-play installation on the Agilent 6890. The D-5 is optimized for trace level work in the electron capture mode, and utilizes the electronics and power supply of the host 6890. Model D-3 is optimized for helium photoionization detection. Available for 110 VAC and 230 VAC.