Drug discovery > Lead Discovery Products & Reviews

MultiSEP™ solid phase extraction wells from Thermo Electron offer robust and reproducible sample preparation and pre-concentration on a routine basis.Wells are available in pre-assembled plate format or as individual wells to allow customisable plates to be assembled by the user.Sorbent packings include the ever-popular silica based bonded phases and also include novel and unique chemistries for specialised applications. Multi…

HyperREZ™ columns are specially designed for analysis of organic acids, alcohols, saccharides and carbohydrates. They employ a polymeric support with ligand exchange groups. The ligand exchange resins contain highly sulfonated cation exchange resins that have Group I, Group II or transition metals associated with the chromatographic surface.HyperREZ™ columns are based upon a polymeric resin that shows stability from pH 1 to 14…

White walled plates enhance luminescent signals and have low background luminescence and fluorescence Flat bottoms with 360 µL total volume Recommended working volumes of 75 to 200 µL Treated for optimal cell attachment Without lids, lids supplied separately Sterilized by gamma radiation and nonpyrogenic Individual alphanumeric codes for well identification Bulk packed 25 per bag

BioBasic 8 Columnso   Improved reproducibility, efficiency and column lifetimeso   Range of stationary phases to optimize selectivityo   Powerful resolution, even on short column lengths Product detail:BioBasic 8 columns provide exceptional reliability for separations of proteins, peptides, and other biomolecules through a combination of high purity silica and reproducible, stable bonding.  The proprietary bonding procedure en…

BetaMax Acid Columns o   High surface area area and bonded phase coverage for maximum retention, even in high percentage organic conditionso   Chemistries for acidic compounds Product detail: For alternative selectivity to traditional alkyl phases, we recommend you try the polar embedded phase BetaMax columns. The stationary phase contains urea groups embedded within the C12 chain, which extra interactions with samples to…

BETASIL C18 Columnso   Broad range of particle sizes and phases for wide method development optionso   High surface area and phase coverage for reproducibility and sharp peak shapes Product Detail BETASIL columns are based on 100Å pore size, fully deactivated type B silica to ensure sharp peaks and excellent reproducibility for the analysis of a wide range of compounds. The 100Å pore size gives a higher concentration of statio…

BetaBasic 4 Columnso   Excellent peak shapes for basic compoundso   Superb stability at both low and high pH Product detail:BetaBasic 4 columns are based on a 150Å pore size, fully deactivated type B pure silica to ensure sharp peaks and excellent reproducibility for the analysis of basic compounds.  Due to stable bonding chemistry and excellent surface coverage, BetaBasic 4 columns show excellent peak shape for basic compound…

Hyperbond™ is a cost effective alternative to µBondapak (a trademark of Waters Corporation). It is based on an irregular silica with 10µm particle size.

o   100% porous graphitic carbon with very different selectivity to reversed-phase silica columnso   Exceptional retention of very polar compoundso   Separation of structurally similar compoundso   Stable from pH 1 to 14 at high temperatures in a wide range of solvents Product detail: Hypercarb is a unique material for HPLC manufactured by Thermo Hypersil-Keystone. Hypercarb consists of fully porous spherical carbon particle…

o  Separate hydrophobic and ionic compounds in a single runo  Select from two mixed mode phases, using either cation or anion exchange combined with C18o  Retention of compounds is optimized using mobile phase pH, ionic strength and percent organic Product detail: Hypersil Duet columns are an ideal choice for unknown compounds and metabolism studies, as they can separate hydrophobic and ionic compounds in a single analysis…

The Hypersil SAX is recommended for analysis of small organic molecules and organic acids. Product detail: Hypersil SAX is a strong anion exchange column, which is typically used for  analysis of small organic molecules and organic acids. As the columns are based on the first generation classical 120Å pore size silica they are not recommended for analysis of biomolecules. For new methods we recommend trying our latest ion…

Thermo Electron Hot and Cool Pockets™ offer unbeatable value in coulmn temperature control. The pockets are small and light weight yet offer precise temperature control. Hot pockerts heat from 5 to 85 oC with a temperature accuracy of ±2oC over the entir range, and a temperature stability of ±0.1Oc. Hot Pockets™ and Cool Pockets™ are not available within the European Union at the present time. We apologise for any inconvenien…

Bottoms are 60% thinner than conventional polystyrene plates, resulting in lower background fluorescent and enabling readings down to 340nm Designed to reduce well-to-well crosstalk during luminescent assays Can be used for both top and bottom reading instruments Not treated (or medium binding) polystyrene surface is hydrophobic in nature and binds biomolecules through passive interactions Is suitable primarily for the i…

A new screw cap that has been introduced for HP users, to enable them to use a screw top vial on a robotic arm autosampler.

Feature uniform skirt heights for greater robotic gripping surface Solvent resistant polypropylene provides compatibility with many common organic solvents (e.g., DMSO, ethanol, methanol) Certified DNase- and RNase-free Total volume is 320 µL; recommended working well volume is 75 to 200 µL Without lids; lids, sealing mats and tapes supplied separately

Cisbio's HTRF® KinEASE™ platform has expanded to include a universal assay for tyrosine kinases. The HTRF KinEASE TK assay is based on our patented HTRF technology and uses a unique tyrosine peptide substrate in combination with a Europium-labeled monoclonal antibody. The HTRF KinEASE™ TK assay has been validated on 59 tyrosine kinases to-date including both receptor and cytoplasmic TKs. A proprietary substrate stabilizing buf…

CLC Combined Workbench includes all features and functions of CLC Free Workbench, CLC Protein Workbench, and CLC Gene Workbench. The program sets new standards for bioinformatics software with its overall graphical display and usability driven, user-friendly interface. In addition, it features a number of unique and innovative bioinformatics tools for supporting advanced biochemistry and molecular biology lab research. CLC Com…

Gentronix has launched a new, accurate and fast in vitro mammalian cell genotoxicity assay - GreenScreen HC. The TK6 host cells are p53 competent and familiar to most genetic toxicology laboratories. A patented GFP reporter system exploits the proper regulation of the GADD45a gene. The assay delivers both high specificity and high sensitivity and detects all common mechanistic classes of genotoxin. The 96-well microplate for…

BioBook (E-WorkBook for biology) delivers complete late stage discovery and early preclinical research data management. Offering a compliant environment with superior flexibility, BioBook (E-WorkBook for biology) simplifies the capture, analysis and reporting of complex, multi-dimensional experimental data, with interactive complex statistics and graphing. BioBook is a robust and easy to use application that controls every st…

The ChromaLynx™ Application Manager automates the processing of LC/MS or GC/MS and LC/MS/MS or GC/MS/MS data. While the high chromatographic separation efficiency and narrow peak widths typical of GC/MS often increase the challenge to identify co-eluting components, ChromaLynx facilitates the rapid detection, identification and semi-quantitative determination of all components. Manually reviewing complex chromatograms to locat…

The HySphere™ cartridge range has been specially developed for the Symbiosis / Prospekt on-line SPE system. The sorbents are exclusively developed by Spark to ensure optimal efficiency and reproducability for a wide range of compounds. The most important feature is the size of the sorbent particles, which is (for most sorbents) < 10 µm as compared to 40 µm in traditional SPE tubes. The elution volume of the 8 µm cartridge is m…

IP-One ELISA assay kit from Cisbio Bioassays - Simple and highly accurate measurement of IP1 IP1, a downstream metabolite of IP3, accumulates in cells following activation of Phospholipase C (PLC) coupled receptors. Among them, the Gq coupled GPCRs represent the most important family of receptors which can activate the β subtype of the PLC family. Other receptor types, like protein tyrosine kinase receptors, antigen or immuno…

With the all new CLC RNA Workbench, CLC bio brings you complex analysis of RNA molecules in a fully integrated, user-friendly and graphically advanced bioinformatics framework. Advanced The CLC RNA Workbench gives the user easy access to a range of complex algorithms and options. RNA secondary structures can be predicted using state-of-the-art free energy minimization algorithms and parameters, thermodynamic and statistical d…

Achieve faster run times and improved sensitivity with a smaller particle size