Drug discovery > Lead Discovery Products & Reviews

HPLC Valves

MIAS-2 readers are a new generation of HTS microscopy readers with an unequaled blend of sensitivity, flexibility and speed.  They are designed to cover the throughput and flexibility needs at multiple phases across the R&D value chain.  In drug discovery R&D, applications include target identification, target validation, assay development, high throughput screening, hit-to-lead, deep pharmacology and ADMET.  Unique features…

Not treated (or medium binding) polystyrene surface is hydrophobic in nature and binds biomolecules through passive interactions Is suitable primarily for the immobilization of large molecules, such as antibodies, that have large hydrophobic regions that can interact with the surface Untreated microplates have a binding capacity of approximately 100 to 200ng IgG/cm2 Without lids, lids supplied separately Total volume is…

CR 2200 is ideal for anyone who needs to perform routine water analysis tests with small sample amounts, as 5 programs are available for digestion of 12 sample cuvettes at 212, 248 and 298.4 °F (100, 120 and 148 °C).

In addition, you can program the CR 3200 to carry out 8 of your individual digestions at freely selectable temperatures up to 338 °F (170 °C).

CR 4200 is the right choice for anyone who needs to perform multiple tests simultaneously, such as COD (298.4 °F/148 °C) and total-N (248 °F/120 °C), as the two thermoblocks for 12 cuvettes each can be controlled separately. It also has memory for 8 of your own user-defined programs with free temperature selection up to 338 °F (170 °C).

Color-coded technical buffer solutions in plastic bottles Order No.      Type No.          pH value at 25 °C       Contents285139156   LC 4004 K     4.00                       250 ml in PE bottle285139189   LC 7004 K     7.00                       250 ml in PE bottle285139218   LC 1004 K     10.00                      250 ml in PE bottle Technical buffer solutions according to DIN 19 267 in canisters(preser ved with Thymol…

Flat bottoms with 360 µL total volume Recommended working volumes of 75 to 200 µL Treated for optimal cell attachment Nonreversible lids with condensation rings to reduce contamination Sterilized by gamma radiation and certified nonpyrogenic Individual alphanumeric codes for well identification Individually wrapped

Recommended working volume of up to 20 to 80 µL Conforms to standard microplate footprint and dimensions High binding surface binds medium (>10kD) and large biomolecules that possess ionic groups and/or hydrophobic regions Binding capacity is approximately 400 to 500ng IgG/cm2 Ideal for immunoassays

Feature uniform skirt heights for greater robotic gripping surface Solvent resistant polypropylene provides compatibility with many common organic solvents (e.g., DMSO, ethanol, methanol) Sterile and DNase- and RNase-free Total volume is 360 µL; recommended working well volume is 75 to 200 µL Without lids; lids, sealing mats and tapes supplied separately

miVac is a range of centrifugal vacuum concentrators and freeze driers capable of removing water and organic solvents from a variety of sample formats including tubes, microplates, and vials. miVac concentrators come in 2 sizes, the smaller Duo and a larger Quattro. There is a choice of vacuum pump and rotor according to application and sample format.  To speed concentration built-in special runs for working with water and…

Double-beam, variable wavelength capability Programmable wavelengths: 190 - 900 nm East-to-use Control Pad Available Lamp startup/shutdown Pre-aligned lamps for easy changeover Remote autozero capability Optimized for use with ESA Coulometric electrochemical detection Low noise and low drift for increasing sensitivity and stability in analyses. The Model 526/528 detectors provide extremely low operating noise levels…

A low volume electrochemical cell optimized for the low flow rates of electrospray ionization mass spectrometry (ESI-MS). • Optimized for incorporation into low flow rate LC-MS applications • Provides high efficiency electrochemical conversion with minimal peak dispersion Proven Coulometric DesignThe Model 5030 Cell utilizes the proven porous graphite flow through design pioneered by ESA and is optimized for incorporation…

An easy way to assess tag accessibilityThe production of fusion proteins often raises the issues not only of their structural integrity after isolation, but also of the accessibility of the associated tag. In the case of GST or 6HIS tagged proteins, this verification can be achieved with HTRF® GST and 6HIS check kits. These two assays are competitive immunoassays in which the anti-GST or anti-6HIS Cryptate conjugates bind dire…

A rapid and sensitive homogeneous assay for cortisol assessmentThe HTRF® cortisol assay can be used for the quantification of cortisol in rodent serum, or directly on cells. This assay has also been validated for 11-beta HSD1 screening on whole cells or microsomes.The assay requires only 2 reagent additions, followed by an incubation period of 2 hours at room temperature. It has a detection limit of 70 pg/mL (e.g. 2 fmol/well…

A straightforward tool for biomolecular labeling with Europium cryptateThe Cryptate labeling kit includes all the necessary materials to allow rapid Cryptate labeling of various biomolecules and purification. The labeling reagent Eu3+-TBP-NHS Cryptate is suitable for labeling peptides, proteins, and oligonucleotides, as well as small molecules containing amino groups (N-terminus or lysine residues). The labeling procedure requ…

A range of HTRF® conjugates for assay developmentHTRF®  toolbox assembles a panel of detecting reagents such as Streptavidin-XLlent!, anti-tag antibodies like Eu-Cryptate anti-GST, 6HIS, DNP and anti species conjugated antibodies offering many possibilities for the study of molecular mechanisms. All reagents are available as Cryptate-Europium or XL665 (the two HTRF tracers) conjugates, to allow easy assay development. These re…

Streamlined single plate protocols including all stimulation and cytokine quantification.The HTRFâ cytokine kit line includes TNFa, IFNg, IL1b, IL6 and IL8 assays. These assays feature no separation steps, a high sensitivity and dynamics, and no use of isotopes. Procedures are performed on a single plate with simultaneous cell stimulation and cytokine detection. They can all be run under a similar experimental procedure stream…

A new secondary messenger for Gq coupled receptor investigation.Cisbio’s IP-One assay, based on its proprietary HTRF® technology, is the first HTS immunoassay that can easily detect inositol(1)phosphate (IP1), a stable second messenger which tightly correlates with Gq-coupled receptor activity. This assay displays all the characteristic advantages of an HTRF® system: totally homogeneous, detection via fluorescence, signal stab…

A fast and reliable process for biomolecule labelingIn many circumstances, assay development and HTS involve specific labeling of the various assay components. Cisbio international’s labeling service is an excellent alternative for the labeling of proteins, peptides, oligonucleotides, or other biomolecules either with Cryptate, XL665, biotin or DNP when you do not have the time or the facilities to label them yourself.Two type…

Rapid Analysis of Multiple 2D Gel Sets DYMENSION 2 has all the features of DYMENSION 1 but has the added ability to detect and compare protein spot maps in multiple gel sets. The software offers many background correction and noise filtering features including a SYPRO® Ruby filter, which can detect and automatically remove spots caused by SYPRO® Ruby crystals adhering to the gel, thus saving users valuable time editing the…

Quick and Easy Analysis of all 2D Gel Applications The exciting DYMENSION 3 software has all the functionality of DYMENSION 2, so can be used to analyse multiple gel sets. In addition, DYMENSION 3 is capable of analysing multi-stained fluorescent gel images stained with up to three contrasting fluorescent labels, for example, Cy™2, Cy™3 and Cy™5. This feature allows users to analyse multiple sets of any type of 2D protein…

Simply multiple: Multi 350i with combined conductivity/oxygen sensor ConOxThe new Multi 350i from WTW, Weilheim, Germany, is a must for anyone who wants to have a versatile high precision multiparameter instrument. In combination with a wide choice of sensors from the WTW program all important parameters of water analysis can be measured: pH, ORP, DO, conductivity, resistance, salinity, TDS, ISE. But there is still more:  With…

Portable Measuring: Environmental monitoring, process control and water analysis with pHotoFlex, pHotoFlex Turb and Turb 430 IRWTW has developed a new line of field instruments based on optical measurement, designated pHotoFlex, pHotoFlex Turb and Turb 430 IR. The instruments have been designed to extract the optimum performance from the latest generation optics optics with state-of-the-art LED technology. Using these optics a…

New in the VARIO family of WTW:The VARIO Cond has a lot to offer – at an excellent price. This economically designed meter is ideal for use in process control monitoring or anywhere a small, accurate meter is needed. The VARIO is small, light, handy, waterproof and has a robust firmgrip rubber armoring. Miniature precision, the VARIO Cond Sets:The VARIO Cond KIT with 4 electrodes conductivity cell: The globally renown measuri…