Drug discovery > Lead Discovery Products & Reviews

This ASPEC system for positive pressure solid phase extraction (SPE) maximizes throughput by processing up to four samples in parallel.

The ASPEC Positive Pressure Manifold uses positive pressure to improve reproducibility and recovery for solid phase extraction (SPE) applications. 

When a smaller, low-flow HPLC system is necessary, look to the VERITY® 241 HPLC System.

Mass-directed detection is now available for your lower capacity VERITY 241 HPLC system with the addition of the VERITY 1900 MS Detector.

Take your VERITY 271 HPLC system a step further with the power of mass-directed detection by choosing the VERITY 1900 MS Detector. 

When large capacity and throughput are needed, the VERITY 281 HPLC systems provide the answer for semi-preparative and preparative purifications.

With the chip-based VERITY 1900 MS Detector, mass-directed detection is now available for your high capacity VERITY 281 HPLC system.

The VERITY Compact CPC-MS System allows you to perform mass-directed purification of target compounds by centrifugal partition chromatography (CPC).

The VERITY® Compact LC-MS System combines the PLC Purification System with the VERITY 1900 MS Detector to provide a compact, easy-to-use, all-in-one instrument for mass-directed purification of target compounds by preparative HPLC and flash chromatography.

The VERITY® GPC Cleanup System is an ideal solution for post-extraction cleanup of high-molecular weight interfering substances from environmental samples, food products, and animal tissue prior to analysis using gel permeation chromatography (GPC). Removal of these contaminants leads to more reliable results, fewer sample repeats, and less downtime for downstream chromatography instruments.

The VERITY® GPC Cleanup System is an ideal solution for post-extraction cleanup of high-molecular weight interfering substances from environmental samples, food products, and animal tissue prior to analysis using gel permeation chromatography (GPC). Removal of these contaminants leads to more reliable results, fewer sample repeats, and less downtime for downstream chromatography instruments.

This liquid handler offers a two-rack platform for large or small volume injection and automatic fraction collection using tubes, vials, or microplates. Its small footprint makes it an ideal choice for labs where bench space is limited.

This small footprint, medium capacity liquid handler and autosampler offers small-to-large volume injection, fraction collection, and liquid handling capabilities. Its dynamic syringeless pumping system is capable of delivering microliters to hundreds of milliliters, with no change in hardware.

This liquid handler provides a versatile, large capacity platform that can be configured for injection, fraction collection, and re-injection as part of a semi-preparative or preparative HPLC purification system. With optional accessories, it can also be used as a flexible liquid handler for performing a wide variety of automated, unattended liquid handling applications.

This VERITY® oligonucleotide purification system offers a single, automated HPLC system for the purification, analysis, and desalting of reagent-grade synthetic oligonucleotides in one continuous run. The system seamlessly changes between preparative and analytical scales, saving time and equipment space, while built-in error handling allows for unattended operation.

Cellpuri® is a disposable chip that enriches cells without the use of centrifugation method. Cells are being separated using the rheological phenomenon inside the microchannels where the cell suspension pass through to filter out waste medium and collect the enriched cells in the outlet.

The XcytoMatic® 40 (XM40™) is a high-throughput cell density and viability analyzer that can run 24 samples in under 14 minutes. The variation between cell counts for these samples is under 3%. If scale-out and scale-up is a concern, you can trust each XM40™ instrument in your production to deliver the same quality results.

Disruptive technology for the characterization of small molecules and fragments. With enhanced sensitivity, expanded thermal options, and advanced microfluidics, the Carterra Ultra™ platform is our most sensitive instrument for interrogating multiple proteins and off-target binding in parallel.

Disruptive Technology for Screening and Characterization. Enhanced sensitivity and fast data collection rate build upon unmatched capabilities in throughput and enable assays such as TPDs/PROTAC®s, kinase, cytokines, DELs, and protein:protein inhibitors.

The AptaFluor® SAH Methyltransferase Assay Kit enables ultra-sensitive, direct detection of SAH—the universal product of methyltransferase reactions—using a riboswitch-based TR-FRET format. With no coupling enzymes required, it delivers high signal-to-background, Z’ ≥ 0.7, and is fully HTS-compatible for drug discovery and inhibitor screening.

BellBrook Labs’ Lead Discovery Services deliver expert support for hit-to-lead efforts. From inhibitor screening and potency profiling to residence-time, mechanism-of-action, and selectivity studies, their team tailors efficient enzymatic assays to your program—accelerating lead advancement with precision and flexibility.

The Transcreener® cGAMP cGAS Assay Kit offers mix-and-read fluorescent detection of cGAMP—the product of cGAS activity—with no coupling enzymes required. Available in FP or TR‑FRET readouts (far-red tracers minimize interference), it’s HTS-ready (Z’ ≥ 0.7), automation-compatible, and validated on 96‑, 384‑, and 1536‑well formats for enzyme kinetics, SAR, and inhibitor screening.

The CD73 activity assay for HTS and hit-to-lead. Measure specific activity of CD73 in a simple mix-and-read format. The kit is designed for compound library screening and follow-up inhibitor discovery.

The Transcreener dAMP Exonuclease Assay directly measures dAMP produced by exonuclease enzymes as they cleave polynucleotides. 

Simplify your workflow and save valuable laboratory time with the fully automated MACS® Sampler, a perfect extension for the MACS® Matchmaker instrument, allowing you to fully integrate automatization solution for your interaction studies.