Drug discovery > Basic Research Products & Reviews
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Products, services, reviews and techniques used in the preliminary investigations of the disease; the cell biology, genetics and protein pathways using tissue culture, cloning and imaging.
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Global DNA Methylation Assay–LINE-1
Active MotifELISA-based assay for the detection and quantification of global DNA methylation in human genomic DNA
RNA Subcellular Isolation Kit
Active MotifAn efficient method to isolate nuclear and cytoplasmic RNA without cross-contamination
Low Cell Number ChIP-Seq Services
Active MotifEnabling generation of genome-wide binding profiles from as few as 10,000 cells
LightSwitch™ Promoter Reporter GoClone™ Collection
Active MotifFor use with The LightSwitch™ Luciferase Assay System for analysis of promoter regulation
LightSwitch™ 3´UTR Reporter GoClone™ Collection
Active MotifFor use with The LightSwitch™ Luciferase Assay System to measure the impact of a 3´UTR on post-transcriptional regulation
miRNA Target IP Kit
Active MotifDesigned to identify the physical interactions of a miRNA with endogenous mRNA transcripts
TransAM® NFκB Transcription Factor Binding Assays, Family Kit
Active MotifSimple plate-based non-radioactive DNA-binding assays that facilitate the study of NFkB transcription factor activation in mammalian tissue and cell extracts
ChIP-IT® Express Enzymatic Kit
Active MotifComplete solution for convenient, accurate monitoring of protein/DNA interactions
TransAM® Nrf2 Transcription Factor Binding Assay
Active MotifSimple solution for studying Nrf2 activation in human, mouse and rat model systems
ChIP-exo High Resolution ChIP Assay
Active MotifAn optimized and streamlined protocol for high-resolution genome-wide mapping of transcription factor binding sites in the human and mouse genomes
ChIP-IT® FFPE Kit
Active MotifProviding the highest quality ChIP-enriched DNA for analysis by qPCR or Next Generation sequencing
ChIP-IT® PBMC Kit
Active MotifSpecially formulated to perform ChIP from PBMCs, including lymphocytes (T cells, B cells and NK cells), monocytes and dendritic cells
enChIP
Active MotifModified ChIP assay that utilizes the CRISPR/Cas9 system to target a specific DNA locus for immunoprecipitation
DNMT Activity / Inhibition Assay
Active MotifHighly sensitive and rapid microplate-based assay to simplify the measurement of DNA methyltransferase activity
Global 5-hmC Quantification Kit
Active MotifELISA-based assay designed to detect and quantify 5-hydroxymethylcytosine (5-hmC) levels in genomic DNA from different sample types
Histone H3 PTM Multiplex Assay
Active MotifMultiplex epigenetic assay for high throughput profiling of histone post-translational modifications
Total Histone H3 ELISA
Active MotifSimple, sensitive method for detecting changes in histone methylation levels from purified core histones or histones isolated by acid extraction
Hydroxymethyl Collector™
Active MotifDetect and capture DNA fragments containing 5-hydroxymethylcytosine (5-hmC) DNA methylation for analysis
hMeDIP Kit
Active MotifImmunoprecipitate and enrich for DNA fragments containing 5-hydroxymethylcytosine (5-hmC)
MeDIP Kit
Active MotifImmunoprecipitate and enrich for single-stranded DNA fragments containing 5-methylcytosine (5-mC)
MethylCollector™ Ultra
Active MotifFast magnetic assay capable of efficiently isolating methylated CpG islands from fragmented genomic DNA
HypoMethylCollector™
Active MotifNovel technology that allows for positive identification of unmethylated DNA fragments
