Drug discovery > Basic Research Products & Reviews

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Products, services, reviews and techniques used in the preliminary investigations of the disease; the cell biology, genetics and protein pathways using tissue culture, cloning and imaging.

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LOBSTR E. coli Expression Strain for One-step Purification

Kerafast

Ideal for low-expressing protein targets, the LOBSTR E. coli expression strain allows for one-step polyhistidine-tag affinity purification by eliminating the two major E. coli contaminants. Traditionally, a major drawback to using polyhistidine-tag affinity purification for proteins expressed in E. coli is contamination resulting from the presence of two naturally histidine-rich proteins in E. coli, ArnA and SlyD. LOBSTR (l…

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IRT-7000 FT-IR Microscope

JASCO (USA)

JASCO also offers the IRT-7000, an innovative FT-IR multi-channel microscope accessory with advanced functionality which drastically improves the ability to obtain microspectroscopic data.The IRT-7000 offers two detectors as standard; a 16-channel linear array detector for infrared sample imaging and a single-point MCT detector. The combination of the standard automatic sample stage and "IQ Mapping" function allows mapping ana…

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LC-4000 Series PDA Detectors

JASCO (USA)

The LC-4000 Series includes three PDA detectors.The MD - 4 017 is a useful replacement for a single wavelength detector, the MD-4015 is the workhor se for UV- visible detection in the range 200 to 600nm and the MD-4010 is designed for high sensitivity and high spectral and time resolution. The MD-4010 PDA detector offers the highest detection sensitivity, equivalent to a single wavelength detec tor. Making use of a 1024 eleme…

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LC-4000 Circular Dichroism Detector

JASCO (USA)

The CD-4095 is a unique HPLC detector for measuring circular dichroism developed from the market leading J-Series circular dichroism spectropolarimeter.Optically active compounds with a chromophore close to a chiral center may absorb circularly polarized light, which can be detected with excellent sensitivity and selectivity. When chiral compounds are measured using a UV-Visible detector, the d- and l- enantiomers cannot be di…

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V-730 UV-Vis Spectrophotometer

JASCO (USA)

User friendly features include the IQ Accessory function for automatic accessory recognition and IQ Start for immediate start of registered data collection applications when conducting routine measurements.Two graphical user interfaces are available including a newly redesigned intelligent remote module (iRM) with a color LCD touch screen or Spectra Manager II software, the latest version of JASCO's innovative, cross-platform…

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V-760 UV-Vis Spectrophotometer

JASCO (USA)

The optical bench in the V-760 UV-visible spectrophotometer utilizes a double monochromator to provide exceptional resolution with extremely low stray light (0.00008%) to assure more precise measurement over the widest photometric range.The V-760 provides excellent sensitivity for diffuse reflectance or transmittance of solid and liquid samples using an integrating sphere. The spectral bandwidth can be set as narrow as 0.1 nm…

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V-750 UV-Vis Spectrophotometer

JASCO (USA)

The optical design employs ‘true double beam optics’ with a chopper providing timed sample, reference and dark current measurements.A high sensitivity PMT (photomultiplier tube) provides accurate and reproducible measurements of both low (and high) concentration samples. By controlling the high voltage applied to the PMT, the dynode feedback circuit allows a wider dynamic range. It also provides excellent sensitivity for diffu…

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V-770 UV-Visible/NIR Spectrophotometer

JASCO (USA)

The V-770 UV-Visible-Near Infrared (UV-Vis/NIR) spectrophotometer features a monochromator with automatically exchanged dual gratings: 1200 lines/mm for the UV/VIS region; 300 lines/mm for the NIR region. A PMT detector is provided for the UV-visible region and a Peltier-cooled PbS detector is employed for the NIR region. Both gratings and detectors are automatically exchanged within the user selectable 800 to 900 nm range.

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V-780 UV-Visible/NIR Spectrophotometer

JASCO (USA)

The V-780 UV-Visible-Near Infrared (UV-Vis/NIR) spectrophotometer features a monochromator with automatically exchanged dual gratings: 1200 lines/mm for the UV/VIS region; 600 lines/mm for the NIR region. A PMT detector is provided for the UV-visible region and a high sensitivity InGaAs photodiode detector is employed for the NIR region. Both gratings and detectors are automatically exchanged within the user selectable 800 to…

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Epigenetics-grade antibodies for ChIP and ChIP-seq

Diagenode

ChIP, ChIP-seq, and methyl antibodies for stem cell studies. In recent years, studies suggest that the mammalian genome undergoes various epigenetic modifications during development and embryonic stem cell (ESC) differentiation. Understanding the mechanisms that control these epigenetic signals is essential in deciphering stem cell biology and the patterns of gene expression during cellular differentiation. ESC gene express…

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Bovine Serum Albumin

Jackson ImmunoResearch Laboratories Inc.

Bovine serum albumin (BSA) is used extensively as a carrier protein to dilute antibodies and as a general protein blocking agent in immunoassays and immunodetection protocols. Our IgG-free BSA, which is also protease-free, should alleviate many of the problems associated with using BSA. Many preparations of BSA, even some of the highest purity grades, contain IgG that may become an antigen for cross-reacting secondary an…

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Antisera to Enzymes, Serum Proteins, & Whole Serums

Jackson ImmunoResearch Laboratories Inc.

Antisera to Enzymes, Serum Proteins, & Whole Serums. Polyclonal antisera from immunized hosts are lipid extracted to improve clarity, salt fractionated, dialyzed against phosphate buffered saline containing sodium azide, and freeze-dried. Antisera against whole serums are obtained by immunizing host animals with whole serum. Antisera against whole IgG molecules [i.e. Anti-IgG (H+L)] are recommended for bridging PAP to prima…

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Solid-Phase Immunoadsorbent Gels

Jackson ImmunoResearch Laboratories Inc.

Solid-Phase Immunoadsorbent Gels. Highly purified IgG from the serum of non-immunized animals is coupled to cyanogen bromide-activated 4% agarose gels for use in preparing affinity-purified antibodies or removing cross-reactive antibodies. Proteins are coupled at a concentration of 1 mg protein per ml of settled gel, and are packaged in phosphate buffered saline with sodium azide.

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