Merck Products & Reviews

The MILLIPLEX® MAP Rat Cardiovascular Disease (CVD) Panel 2 is used for the simultaneous quantification of the following Rat analytes: sE-Selectin, sICAM-1

The MILLIPLEX® MAP Rat Cardiovascular Disease (CVD) Panel 3 is used for the simultaneous quantification of the following Rat analytes: Adiponectin, Fibrinogen

The MILLIPLEX® MAP Rat Endocrine Panel is used for the simultaneous quantification of the following Rat analytes: Amylin (Active), GLP-1 (Active), Glucagon, Insulin, Leptin

The MILLIPLEX® MAP Rat Gut Hormone Panel is used for the simultaneous quantification of the following Rat analytes: Amylin (Active), GIP (Total), GLP-1 (Active), Ghrelin (Active), Insulin, Leptin, PP, PYY (Total)

The MILLIPLEX® MAP Rat Kidney Toxicity Panel I is used for the simultaneous quantification of the following Rat analytes: Clusterin, KIM-1, OPN - Osteopontin

The MILLIPLEX® MAP Rat Kidney Toxicity Panel II is used for the simultaneous quantification of the following Rat analytes: Albumin, Cystatin C, β-2-Microglobulin

The MILLIPLEX® MAP Rat Metabolic Hormone Magnetic Bead Panel is used for the simultaneous quantification of the following Rat analytes: Amylin (Active), C-Peptide 2, Ghrelin (Active), GIP (Total), GLP-1 (Active), Glucagon, IL-6, Insulin, Leptin, MCP-1, PP, PYY, TNF-α

The MILLIPLEX® MAP Rat/Mouse IGF-1 - Single Plex is used for the simultaneous quantification of the following Mouse, Rat analytes: IGF-1

The MILLIPLEX® MAP Rat Pituitary Magnetic Bead Panel is used for the simultaneous quantification of the following Rat analytes: ACTH, BDNF, FSH, GH, LH, Prolactin, TSH

The MILLIPLEX® MAP Rat Thyroid Hormone T3, T4, TSH Panel is used for the simultaneous quantification of the following Rat analytes: T3, T4, TSH

The MILLIPLEX® MAP Rat Thyroid Hormone T3/T4 Panel - 2 Plex is used for the simultaneous quantification of the following Rat analytes: T3, T4

The MILLIPLEX® MAP Human Skin Panel is used for the simultaneous quantification of the following Human analytes: Cortisol, Fibronectin, HSA, Involucrin, Keratin-1,10,11, Keratin-6, LPS

The MILLIPLEX® MAP Steroid / Thyroid Hormone Magnetic Bead Panel is used for the simultaneous quantification of the following Human, Canine analytes: Cortisol, Estradiol, Progesterone, Free T3, Free T4

The MILLIPLEX® MAP TGFbeta 3-Plex is used for the simultaneous quantification of the following Mouse, Human, Rat, Pig, Horse, Rabbit, Guinea Pig, Hamster analytes: TGF-β1, TGF-β2, TGF-β3

EMD Millipore's hERG membrane preparations are crude membrane preparations made from HEK293 stable recombinant cell lines, which are ideal HTS tools for screening antagonists against the hERG channel. The membrane preparations exhibit a Kd of 5.2 nM for [3H]-Astemizole. With 10 μg/well hERG Membrane Prep and 3.0 nM [3H]-Astemizole, a greater than 4-fold signal-to-background ratio was obtained.

EMD Millipore's cAMP HTS immunoassay kit, 384 well is a competitive immunoassay for quantitative chemiluminescence-based detection of cAMP in cell lysates and supernatants, which has been optimized for use in high throughput screening applications. The kit provides two ready to use 384 well pre-coated assay microplates and all reagents required to perform the assay.

Chem-1 cells are an adherent cell line endogenously overexpressing Galpha15 that is used as a host for Chemicon's ChemiScreen™ GPCR Membrane Preparations. Chemicon's ChemiScreen™ Wild-Type Chem-1 Membrane Preparations are ideal controls for validation of radioligand binding assays employing ChemiScreen™ GPCR Membrane Preparations in the Chem-1 host cell line.

Chemicon's cloned human CXCR1-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant CXCR1 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between CXCR1 and its ligands.

EMD Millipore's CXCR1 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of CXCR1 interaction with IL-8. The membrane preparations exhibit a Kd of 0.2 nM for [125I]-IL-8. With 5 μg/well CXCR1 Membrane Prep and 0.1 nM [125I]-IL-8, a greater than 5-fold signal-to-…

Chemicon's cloned human CXCR2-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant CXCR2 expression on the cell surface and contains high levels of the promiscuous G protein Galpha15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between CXCR2 and its ligands.

Chemicon's CXCR2 Membrane Preps are ideal tools for screening for antagonists of interactions between CXCR2 and its ligands. Radiolabeled IL-8 binds to the CXCR2 membranes with a Kd of 0.075 nM. With 0.1 nM 125I-labeled IL-8, a 5-fold window of specific binding is obtained.

Chemicon’s cloned human CXCR3-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant CXCR3 expression on the cell surface and contains high levels of the promiscuous G protein G16 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between CXCR3 and its ligands.

EMD Millipore’s ChemiScreenTM CXCR3 receptor membrane preparations are ideal tools for screening for antagonists of CXCR3 interactions with its ligands. With 0.1 nM 125I-labeled IP10, the CXCR3 membrane preparation at 5 μg/well gives a signal:bakground of greater than 10-fold.

Chemicon's cloned human recombinant CXCR4-expresssing cell lines is made in Chem-1 host, which support high levels of recombinant CXCR4 expression on the cell surface and contains high levels of the promiscuous G protein Galpha15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between CXCR4 and its ligands

Chemicon's CXCR4 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal tools for screening for antagonists of interactions between CXCR4 and SDF-1a. Radiolabeled SDF-1a binds to the CXCR4 membranes with a Kd of 0.9 nM. With 0.04-0.13 nM 125I-labeled SDF-1a, an approximately 3-fold window of specific bin…