Merck Drug discovery > Target Discovery Products & Reviews

Leptin is synthesized in adipocytes as a 16kD molecule and the circulating level is directly proportional to the total amount of fat in the body.

Peptide YY (PYY), a novel 36 amino-acid amidated hormone is a component of the complex neuroendocrine control process.

Insulin, a 5.8 kDa hormone is secreted by the islet beta cells in the pancreas. This kit offers sensitive assay for rat/mouse insulin

Leptin is synthesized in adipocytes as a 16 kDa molecule and the circulating level is directly proportional to the total amount of fat in the body.

Dextran Sulfate (MW 500,000) is used as an additive in probe hybridization solutions. Its presence accelerates the rate of hybridization by 10 fold. The addition of Dextran Sulfate favors the formation of probe networks, resulting in greater sensitivity during membrane-bound nucleic acid analysis. The product is supplied as a 50% (w/v) solution.

Hybrisol® Hybridization Solutions are pre-made, ready-to-use solutions optimized for sensitive single and multiple gene copy detection using membrane-based hybridization techniques. They are designed to give maximum signal and clean background for hybridizations performed on nylon and nitrocellulose membranes. Hybrisol® Solution contains 10% Dextran Sulfate, 1% SDS, 50% Formamide, 6X SSC, Sheared DNA, and Modified Denhardt's S…

The CpGenome™ DNA Modification Kit is used to create methylation-specific sequence alterations in any DNA sample. Using chemical treatment, the kit converts all unmethylated cytosine residues to uracil. Methylated cytosine residues are unaltered in this process. Therefore, the chemically-treated DNA sequence will differ only if it was originally unmethylated in vivo. After sequence conversion, methylation specific PCR is emplo…

The CpGenome™ Fast DNA Modification Kit contains the reagents for the initial bisulfite modification of the DNA required for both methodologies.

The MILLIPLEX® MAP Rat Osteocalcin - Single Plex is used for the simultaneous quantification of the following Rat analytes: Osteocalcin

The MILLIPLEX® MAP Rat OPG - Single Plex is used for the simultaneous quantification of the following Rat analytes: Osteoprotegerin

The MILLIPLEX® MAP Rat RANKL Single Plex is used for the simultaneous quantification of the following Rat analytes: RANKL

The MILLIPLEX®MAP Human Brain-Derived Protein Panel is used for the simultaneous quantification of the following Human analytes: ACTH, AGRP, BDNF, CNTF, FSH, GH, LH, Prolactin, TSH

The MILLIPLEX® MAP TGF beta1 (Transforming Growth Factor Beta) - Single Plex is used for the simultaneous quantification of the following Mouse, Human, Rat, Pig, Horse, Rabbit, Guinea Pig, Hamster analytes: TGF-β1

The MILLIPLEX® MAP Phospho Akt1/PKBα (Ser473) MAPmate is used for the simultaneous quantification of the following Human analytes: Akt (PKB), Akt/PKB (Ser473) - AB1

The MILLIPLEX® MAP Phospho Erk/MAP Kinase 1/2 (Thr185/Tyr187) MAPmate is used for the simultaneous quantification of the following Human analytes: Erk/MAPK 1/2, Erk/MAPK 1/2 (Thr185/Tyr187)

The MILLIPLEX® MAP Phospho EGF Receptor MAPmate is used for the simultaneous quantification of the following Human analytes: EGFR, EGFR (pan Tyr)

The MILLIPLEX® MAP Active Caspase 3 MAPmate is used for the simultaneous quantification of the following Human analytes: Caspase 3, Caspase 3 (Active)

The MILLIPLEX® MAP Total Akt/PKB MAPmate is used for the simultaneous quantification of the following Human analytes: Akt (PKB), Akt/PKB (Total) - AB1

The MILLIPLEX® MAP Total EGF Receptor MAPmate is used for the simultaneous quantification of the following Human analytes: EGFR, EGFR (Total)

The MILLIPLEX® MAP Phospho HSP27 (Ser78) MAPmate is used for the simultaneous quantification of the following Human analytes: HSP27, HSP27 (Ser78)

The MILLIPLEX® MAP Total HSP27 MAPmate is used for the simultaneous quantification of the following Human analytes: HSP27, HSP27 (Total)

The MILLIPLEX® MAP Total Erk/MAP Kinase 1/2 MAPmate is used for the simultaneous quantification of the following Human analytes: Erk/MAPK 1/2, Erk/MAPK 1/2 (Total)

The MILLIPLEX® MAP Phospho p38/SAPK (Thr180/Tyr182) MAPmate is used for the simultaneous quantification of the following Human analytes: p38, p38/SAPK2A/B (Thr180/Tyr182)

The MILLIPLEX® MAP Phospho Rsk1/MAPKAP Kinase 1a (Ser380) MAPmate is used for the simultaneous quantification of the following Human analytes: Rsk1, Rsk1(Ser380)

The MILLIPLEX® MAP Total p38/SAPK MAPmate is used for the simultaneous quantification of the following Human analytes: p38, p38/SAPK2A/B (Total)