TCI CryoProbe by Bruker BioSpin

The TCI CryoProbe is a proton-optimized triple resonance NMR ‘inverse’ probe, featuring three fully independent channels (plus lock channel) for simultaneous decoupling on multiple nuclei such as ¹³C and ¹⁵N.

Triple Resonance Probes give you access to advanced NMR techniques, letting you pulse up to four nuclei in one experiment. The TCI CryoProbe is optimized for ¹H and ¹³C observation. If you add a deuterium lock switch, you can decouple ²H, as well, permitting decoupling of up to four nuclei in a single pulse sequence. Triple (TCI) Resonance Probes are used extensively for the family of double and triple resonance experiments developed to perform NMR structure determination of biological macromolecules.

TCI CryoProbe is equipped with cold preamplifiers for ¹H and ¹³C. Its design in conjunction with the cryogenically cooled preamplifier for deuterium channel guarantees highest sensitivity for the lock channel, resulting in excellent stability of the spectrometer. This also permits the use of as little as a few percent of deuterated solvents. The probe is compatible with shaped tubes for optimum performance on lossy samples.

Technical Details

• Proton-optimized triple resonance NMR probe
• Sensitivity increase on ¹H and ¹³C
• Four fully independent channels (plus lock channel) 
• Simultaneous decoupling on multiple X-nuclei such as ¹³C and ¹⁵N 
• Cooled ²H preamplifier for excellent stability
• Fitted with an actively shielded single axis Z-gradient for all CryoProbes
• Shaped tube application
• Standard sample temperature range 0°C – 80°C (3mm) 
• Standard sample temperature range -40°C – 150°C (5mm)
• ATM (Automated Tuning and Matching) and CryoFit compatible 
• Ideally suited for the research on proteins, small molecules and metabolomic samples