SyncroPatch 384
The SyncroPatch 384 is a revolutionary automated patch clamp system combining high quality electrophysiological data acquisition and analysis with state-of-the-art liquid handling. With 384 amplifier channels and a 384-pipetting head, up to 384 cells can be recorded in parallel, resulting in a throughput of up to 20,000 high-quality data points per day.
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Great machine, users friendly.
Electrophysiology
Great tool to test compound libraries on specific targets. Different functions can be used to investigate further the activity of ion channels
Review Date: 12 Jan 2022 | Nanion Technologies GmbH
Great results and very reliable.
Patch clamp, characterization of ion channels
Very effective, reliable and user friendly.
Review Date: 12 Jan 2022 | Nanion Technologies GmbH
Excellent device, perfect service and team.
Ion Channel Discovery
Device provides easy to use electrophysiological testing and a high-throughput combined with data reliability. Nanion´s product support and development is outstanding.
Review Date: 11 Jan 2022 | Nanion Technologies GmbH
The most valuable tool for characterisation of red blood cell ion channels!
Red blood cell electrophysiology
This is the only automated high throughput patch clamp setup that allows to resolve cell-to-cell differences and characterise the fractions of red blood cells with different properties in human blood.
Review Date: 11 Jan 2022 | Nanion Technologies GmbH
I cannot wait to have the machine available for our research!
Measuring ion transport over cell membranes
The transport of ions over the cell membrane transmits important signals to almost all cell types. It is essential for the survival and function of cells and thereby for our existence and in disease and therapy. The SyncroPatch allows us to study how transport of ions over the cell membrane is regulated in health and disease: much, much more efficient and reliable than the previously available technology. An important breakthrough!
Review Date: 11 Jan 2022 | Nanion Technologies GmbH
Outstanding in drug discovery development!
Drug Discovery & Development
Innovation toward cost effectiveness makes the 384 Automated Patch Clamp System a way to get more reliable results in a short time.
Review Date: 9 Nov 2021 | Nanion Technologies GmbH
Reliable, flexible and easy-to-use automated E'phys system! Highly recommended!
Ion channel electrophysiology
At SB Drug Discovery we have found the SyncroPatch to be an easy-to-use platform that has allowed us to quickly characterise a broad range of voltage-gated and fast ligand-gated ion channels while further improving our efficiency through increased automation. The flexibility offered by the SyncroPatch has enabled us to conduct complex screening assays designed to meet customer demands and expand our ion channel drug discovery capabilities.
Review Date: 19 Jan 2021 | Nanion Technologies GmbH
Great instrument that made my PhD research possible.
Functional screening of ion channel variants (ASIC1a)
I had the chance to use the SyncroPatch for parts of my PhD research, enabling the high-throughput functional characterization of over 300 different ASIC1a variants. Working with transiently transfected cells that were FACS-sorted before the patch-clamp experiments, I didn't expect perfect seals, but I still got good quality data and reproducible results that formed the basis for my PhD project. I measured CRCs for activation and steady-state desensitization, as well as peptide modulation of the channel, and got fantastic support from Søren Friis both with technical questions and assay design. The SyncroPatch and its software are easy to use and allow for versatile assay design. The team at Nanion goes out of their way to help with all questions and requests that come up, and they host fantastic user meetings for idea exchange. After four years using the SyncroPatch, I can highly recommend it.
Review Date: 20 Nov 2020 | Nanion Technologies GmbH
The SyncroPatch 384 is an automated patch clamp instrument with 384 recording channels incorporated into a state-of-art liquid handling robot. It can be used for screening large compound libraries but also for smaller screens and assay development using the 32-well mode of operation. This allows the instrument to be literally turned into a lower throughput instrument, using a fraction of the chip and pipetting head in multiples of 32 wells.
The SyncroPatch 384 can be used in all stages of drug discovery, from hit discovery through lead optimization to safety pharmacology, and can also be used for complex biophysical analysis of ion channels in academic research. Our dedicated team of electrophysiologists and engineers are committed to continuous in-house assay development, software, and hardware advancements, ensuring fast and custom-tailored solutions for your assay demands.
Benefits:
384 recording in parallel
32-well mode for smaller projects or assay development
Single- or multi-hole chips
Giga-seal recordings with up to 95% success rate.
Sample collection for concentration verification.
Up to 20,000 data points per day.
Advanced temperature control
Voltage and current clamp as standard
Unlimited compound application due to waste removal
On-deck compound preparation
Internal solution perfusion
Chips produced in-house; various resistances available.
Introducing SyncroPatch 384: Technical specifications brochure with interactive links
In this application note, Nanion Technologies presents the SyncroPatch 384, an advanced automated patch clamp system. It features a 32-well mode for flexible usage and cost-effective utilization of the NPC-384 chip. With advanced temperature control, current clamp capability, on-board cameras, and compliance with CiPA guidelines, it is suitable for various applications. The system offers a redesigned patch clamp module, HTS compatibility, and a user-friendly deck layout with integrated cameras. The RecoBox provides easy access to essential functions. The NPC-384 chip is available in different types and ensures accurate compound concentrations. The software package includes PatchControl 384 and DataControl 384 for data recording and analysis.
High-throughput automated patch clamp in drug discovery
In this application note, discover how innovations in automated patch clamp technology have accelerated drug discovery from hit finding to target validation. Learn about the new SyncroPatch 384, an automated patch clamp system consisting of a patch-clamp module integrated into the pipetting robot – Biomek i5. With 384 amplifier channels and a 384-pipetting head, all 384 cells are recorded in parallel, resulting in a throughput of up to 20,000 data points per day.
Stable recordings and high-throughput pharmacology of Assay Ready Ca<sub>V</sub>1.2 cells on the SyncroPatch 384
In this application note, Nanion Technologies presents high-quality data with reliable pharmacology on Assay Ready CaV1.2 Cells at a high throughput collected on the SyncroPatch 384.
Characterization of hClC-1 on the Syncro-Patch 384
In this application note, Nanion Technologies presents data conducted on the SyncroPatch 384 showing characteristic biophysical properties and pharmacology of hClC-1 expressed in CHO cells.
High-throughput pharmacology of Na<sub>V</sub>1.9 channels on Nanion’s SyncroPatch 384
In this application note, Nanion Technologies presents high-quality data with reliable pharmacology on hNaV1.9 expressing HEK293 cells at a high throughput collected on the SyncroPatch 384.
Increase throughput by recording in unattended mode on the SyncroPatch384
This application note demonstrates recordings of hNaV1.5 expressed in CHO cells on the SyncroPatch 384 in unattended mode. In a 6 hour period, 10 compound plates were prepared, 10 NPC-384 chips were recorded and success rates, IC50s and Z’ values were calculated using 7 different compounds in duplicate on each plate, along with positive and negative controls.
Patch clamp made easy
Conventional patch clamp remains the gold standard for the investigation of ion channels and is widely used in the area of drug discovery, safety pharmacology and basic research in academia and industry. The conventional patch clamp method requires skilled personnel to perform the experiments and is notoriously low throughput because only 1 cell can be recorded at a time. This short e-book is designed to give you an introduction to ion channels and the methods to record them.
Na<sub>V</sub>1.5-ΔKPQ late I<sub>Na</sub> current properties and pharmacology on the SyncroPatch 384i
Here Nanion Technologies GmbH, presents data collected on the Syncro- Patch 384i showing the peak and late INa current recorded from WT and NaV1.5-ΔKPQ cell lines. Peak current could be reliably recorded from both cell types. In WT cells, late INa was negligible in the absence of ATX-II, whereas the late INa from NaV1.5-ΔKPQ cells could be reliably recorded. Peak current from WT, and peak and late INa from NaV1.5-ΔKPQ was inhibited by ranolazine and mexiletine and IC50 values agreed well with the literature6.
High throughput screening of cardiac ion channels
Here Nanion Technologies GmbH, presents high-quality data with reliable pharmacology on hERG expressing CHO cells, NaV1.5, CaV1.2 or KvLQT1 expressed in HEK293 cells and Kir2.1 expressed in RBL cells on the SyncroPatch 384PE or Patchliner. Additionally, electrophysiological recordings on the Patchliner and Impedance measurements on the CardioExcyte 96 of stem cell-derived cardiomyocytes are shown.
Introducing the SyncroPatch 384
In this video, Nanion Technologies introduces the SyncroPatch 384, the company's newest generation automated patch clamp system. The SyncroPatch 384 promises to take the versatility and flexibility of automated patch clamping to new levels, and is equally well suited for large unattended high-throughput screening campaigns in the pharmaceutical industry, small compound screens, and academic research.
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