RenataDX System
Effective dried blood spot analysis.
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The RenataDX™ System is a fully integrated flow-injection tandem mass spectrometry (FIA-MS/MS) IVD system for high-throughput dried blood spot analysis that delivers a robust and streamlined platform with the familiar workflow you rely on and provides:
- High-throughput analysis of analytes from dried blood spots and other human biological matrices
- Fully integrated bench-top system
- Compatibility with laboratory-developed tests (LDTs) and third-party reagent kits
- Industry-standard software workflows
The Clinical Services program also provides priority service to minimize any disruptions.
Trusted technology:
System components include the 3777C IVD Sample Manager, ACQUITY™ UPLC™ I-Class IVD Binary Solvent Manager, and Xevo™ TQD IVD Mass Spectrometer that fits easily onto your benchtop. Fully optimized for diagnostics, the RenataDX System also includes:
- An easy-to-use software interface
- The ability to import sample worklists from 3rd party sample preparation equipment
- Tool-free and rapid ESI source cleaning
Acquire and process samples efficiently and securely:
MassLynx™ (IVD) Software streamlines your data workflow with integrated data acquisition, processing, and reporting through laboratory information management systems (LIMS) and third-party middleware applications.
The IonLynx™ Application Manager can run simultaneously with data collection, meaning your results can arrive in real-time. User-definable reports ensure your results are presented exactly as you want them consistently. Applying MassLynx Basic Security, your results can have enhanced security and traceability.
System flexibility to suit your laboratory's needs:
Due to its open-platform design, the RenataDX System can be adapted to your laboratory workflow.
- The flexibility to run any FIA-MS/MS laboratory-developed test or reagent kit
- The ability to tailor system parameters, such as your own MS methods, sample injection volumes, and wash settings
- Adjustable sample plate set-up to accommodate high-volume samples
Robust and reproducible data:
High-throughput, routine operation complex matrices such as dried blood spots are uncompromised with low carryover and high reproducibility, providing you with the highest confidence that your results will arrive on-time, every time.
RenataDX System: Analytical performance for butyl esters of amino acids, free carnitine, and acylcarnitines in dried blood spots
The Waters RenataDX Screening System enables flowinjection analysis and quantification of organic compounds in biological matrices. In this application note, Waters describes a test of the analytical performance of the RenataDX Screening System for the analysis of butyl esters of amino acids, free carnitine, and acylcarnitines in dried blood spots. Dried blood spot (DBS) control samples were extracted. Derivatized extracts from DBS control samples were analyzed with the RenataDX System, under the control of MassLynx IVD Software (v4.2), with data processed using IonLynx Application Manager. Here, the Waters RenataDX System has demonstrated the capability to measure a subset of butyl esters of amino acids, free carnitine, and acylcarnitines. The endogenous concentration of arginine was near the limit of detection of the RenataDX System.
RenataDX System - Tips and Tricks for Flow-Injection Tandem Mass Spectrometry (FIA-MS/MS)
To ensure high-quality and consistent data, appropriate system setup, optimization, and maintenance should be considered allowing for minimal need of ongoing user suprvision or intervention. This white paper describes key steps that support the generation of high-quality analytical data by FIA-MS/MS, using the Waters RenataDX™ System, as well as how to recognize common system occurrences that can negatively affect data quality.
RenataDX Screening System: Analyzing amino acids, free carnitines and acylcarnitines in dried blood spots
The Waters™ RenataDX™ Screening System enables flow-injection analysis and quantification of organic compounds in biological matrices. In this application note, discover the analytical performance of the system for the analysis of amino acids, free carnitines, and acylcarnitines in dried blood spots.
Existing challenges in clinical LC-MS and how to overcome them
In this white paper, SelectScience and Waters explore some of the common challenges encountered by laboratories looking to transition to mass spectrometry-based testing and provide simple solutions to overcoming these.
RenataDX Screening System: Technical overview
In this video, Waters Corporation gives a detailed look at its RenataDX™ Screening System, a fully integrated flow-injection tandem mass spectrometry (FIA-MS/MS) IVD system for high-throughput dried blood spot analysis that promises to deliver a robust and streamlined workflow.
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