Why does CN Bio offer NASH Fee-For-Service?
Despite a desperate need for NAFLD/ NASH therapeutics, we continue to observe late-stage candidate failures within the clinic, which in part can be attributed to the fact that existing preclinical models do not adequately predict human responses. CN Bio’s NASH Fee-For-Service program is designed to help circumvent this issue, enabling better-informed decisions about NAFLD/ NASH lead candidates ahead of the clinic.
Which in vitro NAFLD/ NASH model does CN Bio use?
In just a few weeks and at a lower cost than animal studies, CN Bio can provide you with human translatable data generated using one of the most advanced NAFLD/ NASH in vitro models available.
This model, developed by CN Bio, utilizes proprietary liver-on-chip technology which enables the longer-term in vitro culture (>1 month) of primary liver cells in 3D microtissue structures. Importantly, it captures the following key aspects of human disease:
Disease progression, as well as the health of liver cell types, is monitored against a range of different target pathways using a range of -omics, microscopy and biomarker assays.
What types of screens does CN Bio offer?
This complex, human-relevant NAFLD/ NASH 3D in vitro model can be used to screen for:
Why should I add another pre-clinical test into our workflow?
The translatable, human-relevant data generated using CN Bio’s model can be used to support (or call into question) the conclusions of internal pre-clinical studies, thus helping to prioritise lead candidates, fail flawed candidates, identify target clinical trial cohorts or optimize dosing regimens with greater confidence.
What are the benefits?
CN Bio’s NASH Fee-For-Service provides: