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Human Recombinant IL-2 (E. coli-expressed) by STEMCELL Technologies Inc.

Manufacturer STEMCELL Technologies Inc.  |   Model: 78220
5.0
/
5.0
  |  1 reviews
Interleukin 2
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Human Recombinant IL-2 (E. coli-expressed) by STEMCELL Technologies Inc. product image
Human Recombinant IL-2

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Average Rating: 5.0
1 Scientist has reviewed this product

5 out of 5
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money


  • Status:

    Reviewer
  • Member since: 2022

  • Organization: University of Houston



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Great results and can’t perform experiment without this.
Rating: 5.0

  • Application Area: T cell activation

"Using this product is efficient to produce activation of the T cell and which is also reproducible. At the same time the price for this product is perfect with the quantity."

Review date: 17 Apr 2023 | Human Recombinant IL-2 (E. coli-expressed)

Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor (Gaffen & Liu). It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma et al.). The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts. IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ T regulatory cells, and affects development of follicular helper T cells. IL-2 also controls inflammation by inhibiting Th17 differentiation (Banchereau et al.). High IL-2 levels in serum are associated with progression of scleroderma, rheumatoid arthritis, and gastric and non-small cell lung cancer, though no known disease can be directly attributed to the lack or excess of IL-2 (Gaffen & Liu). Human Recombinant IL-2 has a serine substitute for cysteine at position 126.

Product Overview

Human Recombinant IL-2 (E. coli-expressed) by STEMCELL Technologies Inc. product image

Human Recombinant IL-2 (E. coli-expressed)

Manufacturer STEMCELL Technologies Inc.

5.0 / 5.0 | 1 reviews