Member since: 2021
Organization: Stanford University
Application Area: Measuring biological clock
"It was easy and reliable. Zymo is super responsible for a quality of samples and process."
What is the DNAge Epigenetic Clock
Aging is the largest risk factor for many chronic diseases including cancer, cardiovascular disease, arthritis, osteoporosis, and type 2 diabetes. Therefore, quantifying the biological age is a fundamental step of understanding diseases and designing anti-aging intervention. Dr. Steve Horvath's epigenetic clock, the gold standard of aging clocks, predicts biological age by measuring DNA methylation at multiple sites.
Accelerated epigenetic age has been associated with a lot of age-related conditions and diseases by independent research studies such as certain types of cancer, obesity and frailty. Recently, a small clinical trial showed that the epigenetic clock, in agreement with the immunological and thymic measurements, could be turned back by a 3-part treatment cocktail. This indicates the power of epigenetic clock in identifying the effectiveness of anti-aging intervention on an accelerated timescale.