Dianthus for challenging affinity screening
Dianthus is a plate-based, microfluidics-free affinity screening platform that measures under controlled equilibrium conditions and in-solution. With two biophysical modalities - Spectral Shift and TRIC - Dianthus excels at challenging interactions that involve molecules like PROTAC ternary complexes, intrinsically disordered proteins, and fragment libraries.
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It was awesome and the right one to use
Protein characterization, Amino acid, tissue, nucleic acid
The equipment in giving an effective and accurate on terms of result
Review Date: 26 Sept 2022 | NanoTemper Technologies
Dianthus is a plate-based and microfluidics-free affinity screening platform. Measurements are performed in solution and are mass-independent — ideal for succeeding at demanding screening campaigns With two methods for measuring molecular interactions, Spectral Shift and TRIC, Dianthus delivers high-quality data and requires less assay development to give you results from real-life samples
Today, the most important drug targets are super challenging when it comes to affinity screening. Immobilization-dependent SPR struggles with applications involving PROTAC binary and ternary complexes and intrinsically disordered proteins. These are precisely the applications where Dianthus excels
Here’s what makes Dianthus the perfect choice for challenging affinity screening campaigns:
- High signal-to-noise ratio: Reliable affinity measurements
- Mass independence: Measure binding with small and large molecules
- Broad range of affinities: From picomolar to millimolar for detection of strong and weak binders
- In-depth understanding of sample quality: Insights into aggregation induced by ligand
Dianthus' 384-well format and gRPC framework means it can be seamlessly integrated into many automation solutions that include robotic liquid handling and plate feeders for hours of uninterrupted and unattended operation
