Leptin Knockout Rat — KiloRat™ by SAGE Labs

Manufacturer SAGE Labs
Leptin is essential for energy intake and expenditure. It is one of the most important adipose-derived hormones, being primarily expressed in adipocytes of white adipose tissue. Loss of function of Leptin creates an uncontrolled appetite leading to severe obesity and abnormal metabolism, making this a useful model for the study of lifestyle diseases, such as obesity, diabetes, atherosclerosis, high cholesterol and high blood pressure.Leptin Knockout Rat — KiloRat™ Characteristics: This mode... Read more


Leptin Knockout Rat — KiloRat™ by SAGE Labs product image
Leptin Knockout Rat — KiloRat™

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Leptin is essential for energy intake and expenditure.

It is one of the most important adipose-derived hormones, being primarily expressed in adipocytes of white adipose tissue. Loss of function of Leptin creates an uncontrolled appetite leading to severe obesity and abnormal metabolism, making this a useful model for the study of lifestyle diseases, such as obesity, diabetes, atherosclerosis, high cholesterol and high blood pressure.


Leptin Knockout Rat — KiloRat™ Characteristics:

  • This model possesses a 151 bp deletion within Exon 1 on chromosome 4
  • Homozygous knockout rats display loss of Leptin protein via Western blot
  • Homozygous knockout rats demonstrate significant weight gain compared to wild type littermates
  • Homozygous knockout rats demonstrate insulin resistance
  • Homozygous knockout rats show greatly elevated serum cholesterol levels
  • Background Strain: Sprague-Dawley

Research Applications:

  • Obesity
  • Type II diabetes
  • Atherogenesis
  • Atherosclerosis
  • Hypertension
  • Insulin resistance
  • Lipoprotein/Cholesterol transportation
  • Metabolism (Triglyceride/Cholesterol)

Product Overview

Leptin Knockout Rat — KiloRat™ by SAGE Labs product image

Leptin Knockout Rat — KiloRat™

Manufacturer SAGE Labs

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